Biochemical Role of Long Non-coding RNA MALAT 1 and Serum Tumor Necrosis Factor Alpha in Bronchial Asthma Patients.

Completed

• Conditions: Bronchial Asthma

• Registration Number: NCT06459895
• Lead Sponsor: Sohag University

Brief Summary

Bronchial asthma affects more than a quarter of a billion people worldwide. It is responsible for over 1000 deaths a day, of which the majority are preventable (Levy, 2015).

Asthma is a common heterogeneous disease characterized by chronic airway inflammation. It is defined by the history of variable respiratory symptoms, such as shortness of breath, chest tightness, wheezes, and cough, together with variable expiratory airflow limitation. Airflow limitation may later become persistent (GINA, 2023).

The diagnosis of asthma is based on the history of these characteristic symptoms and evidence of variable expiratory airflow limitation from bronchodilator reversibility testing or other tests (GINA, 2023).

Detailed Description

Not available

Study Timeline

• Study Start: 2024-04-16
• Status Verified: 2024-06
• Primary Completion: 2024-06-10
• Study Completion: 2024-06-10
• Study First Submitted: 2024-06-10
• Study First Submitted QC: 2024-06-10
• Last Update Submitted: 2024-06-10
• Study First Posted: 2024-06-14
• Last Update Posted: 2024-06-14

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 194

Inclusion Criteria

• All patients were admitted to Sohag University Hospital, chest department DIAGNOSED AS BRONCHIAL ASTHMA

Exclusion Criteria

• Patients with malignancies, major trauma or surgery, and acute or chronic infectious diseases were excluded.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Long non-coding MALAT1 gene expression assay:	2 MONTHS	Gene expression assay by RT-PCR reaction

Secondary Outcome Measures

Name	Time	Method
TNF-alpha	2 MONTHS	measured in serum by ELISA

Trial Locations

Locations (1)

Sohag University Hospital; 🇪🇬 Sohag, Egypt