Primed vs Unprimed Facilitatory and Depressive Paired Associative Stimulation

Not Applicable

Completed

• Conditions: Healthy
• Interventions: Device: Transcranial Magnetic Stimulation (Magstim)

• Registration Number: NCT02619643
• Lead Sponsor: University of Minnesota

Brief Summary

Following brain injury (e.g. stroke), application of non-invasive brain stimulation may improve rehabilitative efforts. However, the most effective method of non-invasive brain stimulation is unknown. Paired associative stimulation (PAS) is a method of non-invasive brain stimulation that pairs an electrical peripheral nerve stimulus with a magnetic stimulus to the head. This method can be applied in a manner that increases (facilitates) or decreases (depresses) excitability within the brain. Furthermore, applying two consecutive PAS sessions within minutes of each other (called primed PAS) may augment changes in excitability more than a single PAS session alone.

Thus, the purpose of this study is to compare the effect of a double PAS session (primed PAS) to the effect of a single PAS session (unprimed PAS) and a sham PAS session in healthy individuals.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2015-11-25
• Study First Submitted QC: 2015-11-30
• Study Start: 2015-12
• Study First Posted: 2015-12-02
• Primary Completion: 2017-12
• Study Completion: 2017-12
• Status Verified: 2019-10
• Last Update Submitted: 2019-10-30
• Last Update Posted: 2019-11-01

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 32

Inclusion Criteria

• ≥ 18 and ≤ 30 years of age
• Elicitable motor evoked potential from the motor cortex contralateral to the dominant hand
• Elicitable N20 sensory evoked potential

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Exclusion Criteria

• History of neurological disease
• Seizure within the past 2 years
• Currently taking epileptogenic medication
• Peripheral neuropathy
• Cognitive impairment and/or major psychiatric disorder
• Metal in the head (dental permitted)
• Pacemaker or other indwelling devices
• Pregnancy

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Arm && Interventions

Group	Intervention	Description
Sham PAS	Transcranial Magnetic Stimulation (Magstim)	A single session of sham paired associative stimulation (PAS) using transcranial magnetic stimulation will be applied
Unprimed PAS 2B	Transcranial Magnetic Stimulation (Magstim)	A single session of active paired associative stimulation (PAS) using transcranial magnetic stimulation will be applied.
Primed PAS 2C	Transcranial Magnetic Stimulation (Magstim)	Two sessions of paired associative stimulation (PAS) using transcranial magnetic stimulation will be applied consecutively (within minutes).
Primed PAS 1C	Transcranial Magnetic Stimulation (Magstim)	Two sessions of paired associative stimulation (PAS) using transcranial magnetic stimulation will be applied consecutively (within minutes).
Primed PAS 1A	Transcranial Magnetic Stimulation (Magstim)	Two sessions of paired associative stimulation (PAS) using transcranial magnetic stimulation will be applied consecutively (within minutes).
Unprimed PAS 1B	Transcranial Magnetic Stimulation (Magstim)	A single session of active paired associative stimulation (PAS) using transcranial magnetic stimulation will be applied.
Primed PAS 2A	Transcranial Magnetic Stimulation (Magstim)	Two sessions of paired associative stimulation (PAS) using transcranial magnetic stimulation will be applied consecutively (within minutes).

Primary Outcome Measures

Name	Time	Method
Change from baseline resting motor threshold	Immediately before and within 60 minutes following intervention	Single-pulse TMS will be used to evoke a motor response that is recorded using electromyography (EMG). The lowest stimulator output needed to elicit a consistent response will be recorded.
Change from baseline peak-to-peak amplitude of motor evoked potential	Immediately before and within 60 minutes following intervention	Single-pulse TMS will be used to evoke a motor response that is recorded using electromyography (EMG). The peak-to-peak amplitude of the EMG response will be measured.