Effect of in-situ application of Simvastatin gel in the surgical management of osseous defects in Chronic periodontitis- A clinico-radiographic study.

The present was conducted to evaluate the periodontal tissue response to in-situ gel using simvastatin with carbolopol 934 p (as a vehicle) after surgical debridement of periodontal osseous defects by recording various clinical parameters , Gingival index (GI), Probing pocket depth (PPD) , Plaque index (PI) and Clinical attachment level (CAL ) and Radiographic paramers (Bone fill) at the end of 3 months, 6 months and 9 months.

Results of this studied showed improvement in both clinical and radiographic parameters in both experiment (Group 1) and Control group (Group 2). But, improvement in clinical and Radiographic parameters (Amount of bone fill) in experiment group was statistically highly significant than control group. Results of this study was in accordance with previously conducted study by Pradeep A.R et al - 2010 and Stein D et al 2005. Various studies e.g Mundy et al 1999, Yazawa H et al 2005,Nyan M et al 2007   have also shown the bone anabolic effect of Simvastatin.

This study has concluded that Simvastatin  as a non space occupying host modulatory pharmacologic agent in the form of in-situ gel as an adjunct to mechanical and surgical treatment approaches may be the future potential application in regenerative periodontal therapy. However, more randomized controlled trial with long term followup to be conducted to proclaim the observations of this study.