Do pesticides cause pemphigus?
Not Applicable
- Registration Number
- CTRI/2019/02/017431
- Lead Sponsor
- Indian Association of Dermatologists Venereologists Leprologists
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Yet Recruiting
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
1.Living spouse
2.Living together and eating in the same household
3.The male of the couple is engaged in spraying/ selling/ otherwise handling pesticide and the female counterpart is engaged only in household work.
Exclusion Criteria
1.Known neurological disease
2.On treatment with cholinergic or anti-cholinergic drugs
3.Already known cases of pemphigus
4.First or second degree relative of each other before marriage
5.Handling or storing pesticides in the living area of home which might lead to exposure of pesticides to the spouse as well
6.Using protective equipment as per standardized recommendations while handling pesticides, thereby leading to negligible exposure to pesticides.
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Assessment of serum anti-desmoglein/ anti- muscarinic acetyl choline receptor antibodies titers as surrogate markers for pemphigus among occupationally pesticide exposed and non-exposed subjects.Timepoint: Being a cross-sectional study, the serological outcome shall be assessed at study inclusion.
- Secondary Outcome Measures
Name Time Method To assess the levels of pesticides in exposed and non exposed study participants and correlate this with anti-desmoglein/ anti-muscarinic acetyl choline receptor antibodies titers.Timepoint: No secondary outcome to assess- not applicable.