Myocarditis Causing Premature Ventricular Contractions:Insights From the MAVERIC Registry
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 100
- 试验地点
- 1
- 主要终点
- Identify the underlying myocarditis in patients presenting with PVCs with or without reduced LVEF
研究概览
简要总结
To assess potential link between unrecognized myocardial inflammation (myocarditis) and premature ventricular contractions (PVCs) associated with and without reduced Left ventricular ejection fraction (LVEF) through comprehensive diagnostic work up.
详细描述
Hypothesized that occult inflammation is clinically under-recognized in patients with symptomatic PVCs with and without Left ventricular (LV) dysfunction and can be a potential link between the 2 conditions. Aimed to evaluate the incidence of underlying inflammation using the Positron emission tomography (PET) scan in patients presenting with symptomatic PVCs enrolled retrospectively in the MAVERIC registry.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients > 18 years of age with mono-morphic or polymorphic PVC burden of ≥5000 in 24 hours.
- •Non-sustained VT was defined as ≥3 more consecutive beats lasting <30 seconds
排除标准
- •History of myocardial infarction,
- •Significant flow-limiting coronary artery disease (≥50% stenosis) on invasive coronary angiography or CT angiography,
- •History of revascularization,
- •Significant symptomatic atrial arrhythmias associated with LV dysfunction,
- •Severe valvular disease,
- •Cardiomyopathy attributed to toxins such as alcohol and illicit drugs,
- •History of cardiac arrest,
- •History of channelopathies or inherited arrhythmias.
结局指标
主要结局
Identify the underlying myocarditis in patients presenting with PVCs with or without reduced LVEF
时间窗: Retrospective Collection between dates January 2014-January 2023
To identify the underlying myocarditis in patients presenting with PVCs with or without reduced LVEF through laboratory testing, FDG-PET(18F-2-fluoro-2-deoxy-D-glucose fluorodeoxyglucose - positron emission tomography) scan, Cardiac Magnetic Resonance imaging and/or Endomyocardial biopsy.
次要结局
- Ascertain whether immunosuppressive therapy (IST) affords short term and long term improvement of LVEF and clinical outcomes(Retrospective Collection between dates January 2014-January 2023)