Pharmacology and Physiology of the Lower Urinary Tract
- Conditions
- Urologic Diseases
- Registration Number
- NCT00662064
- Lead Sponsor
- University College London Hospitals
- Brief Summary
The function of the lower urinary tract is simple - urine storage and voiding. However, despite this simplicity of function, the control of the lower urinary tract is a rather complex, multilevel process (urothelium, detrusor, peripheral nerves, spinal cord and higher cerebral centres) and the mechanisms involved remain poorly elucidated.
This study is designed to gain a more in depth understanding of the lower urinary tract function. Using bladder biopsies, tissue staining for characteristic markers present on nerves and other cells will be performed. We hypothesize that certain markers are altered in disease and turn back towards the control level of healthy people or patients with successful medical treatment.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 200
- Patients with lower urinary tract dysfunction
- Controls with normal lower urinary tract function
- Age < 18 years old
- Pregnancy
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Immunohistochemistry + PCR of bladder tissue not specified (storage of biopsies)
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Department of Uro-Neurology, The National Hospital for Neurology and Neurosurgery
🇬🇧London, United Kingdom