NCT06706947尚未招募不适用
Exploration of the Efficacy and Mechanisms of Lymphaticovenous Anastomosis in the Treatment of Alzheimer's Disease
Luo Xinxin1 个研究点 分布在 1 个国家目标入组 20 人开始时间: 2024年12月1日最近更新:
适应症
干预措施
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 20
- 试验地点
- 1
- 主要终点
- Mini-Mental State Examination(MMSE)
研究概览
简要总结
The aim of this clinical trial is to determine whether Lymphaticovenous Anastomosis can treat Alzheimer's disease，in AD patients aged 18-80.he main questions it aims to answer are:
- Can Lymphaticovenous Anastomosis improve cognitive function, daily living ability, mood, or sleep status in patients with Alzheimer's dementia, demonstrating good therapeutic efficacy?
- Does deep Lymphaticovenous Anastomosis lead to changes in peripheral blood biomarker levels, neuroinflammatory responses, and neuroimaging in patients with Alzheimer's dementia?
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •At least two deputy chief physicians or above, diagnosed with Alzheimer's dementia according to the DSM-5 diagnostic criteria;
- •Age between 18-80 years old;
- •The course of the disease is at least 1 year;
- •MMSE score ≤ 24 points; MoCA score < 26
- •Brain MRI shows hippocampal atrophy;
- •Patients and their families agree to participate in this project for surgical treatment and sign an informed consent form.
排除标准
- •Individuals with contraindications for Lymphaticovenous Anastomosis; those allergic to anesthetics and contrast agents (indocyanine green);
- •Those unable to cooperate with cranial magnetic resonance imaging and scale testing;
- •Patients simultaneously suffering from schizophrenia, depression, bipolar disorder;
- •Patients with severe somatic diseases (such as cardiovascular, liver, kidney, gastrointestinal, etc.), infectious diseases, and immune system disorders;
- •Individuals with serious neurological diseases (such as epilepsy, cerebrovascular diseases, etc.), other types of dementia, mental retardation;
- •Pregnant or lactating women.
研究组 & 干预措施
Lymphaticovenous Anastomosis
Experimental
干预措施: Lymphaticovenous Anastomosis (Procedure)
结局指标
主要结局
Mini-Mental State Examination(MMSE)
时间窗: half a year
次要结局
未报告次要终点
研究者
Luo Xinxin
Director
Zhongshan Third People's Hospital
研究点 (1)
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