Developing mathematical methods for non-invasive reconstruction of electrical heart activity from body-surface electrocardiograms and a CT-based torso-heart geometry

Recruiting

Conditions: arrhythmia
heart rhythm disorder
10007521

Registration Number: NL-OMON53169

Lead Sponsor: Medisch Universitair Ziekenhuis Maastricht

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Recruiting

Sex: Not specified

Target Recruitment: 65

Inclusion Criteria

The patients will be selected from the population base at the cardiology department of MUMC+, both admitted and non-admitted (outpatient) care. Patients are only eligible if 18 years or older and able to provide informed consent. Patients are included from two groups. One group has a medical indication for a cardiac CT scan (unrelated to this research), whereas the other has no medical indication for CT. Only patients from the CT-group are suitable for inverse reconstruction of electrical heart activity. ;All patients referred for cardiac CT are eligible for inclusion in the first study group. ;For the second group, inclusion criteria are one or more of the following:
* Conditions that might alter electrical conduction properties in the heart, including (but not limited to): Brugada syndrome (BS), Arrhythmogenic right ventricular cardiomyopathy (ARVC).
* Implanted cardiac device, such as pacemaker or implantable cardioverter defibrillator

Exclusion Criteria

Known strong reaction against electrode attachment

Study & Design

Study Type: Interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The primary study endpoint is further development and validation of<br /><br>mathematical methods and recording techniques, to reconstruct epicardial<br /><br>potentials from BSPs and a torso-heart geometry. This development and<br /><br>validation can only be performed when BSP and torso-heart geometrical data are<br /><br>available. </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>The secondary study endpoints include disease-specific abnormalities in<br /><br>epicardial reconstructions or in body-surface potential maps.</p><br>