Biological Variation of Cardiac Biomarkers in Aortic Valve Stenosis
Completed
- Conditions
- Aortic Valve Stenosis
- Interventions
- Other: No intervention
- Registration Number
- NCT02510482
- Lead Sponsor
- Maastricht University Medical Center
- Brief Summary
Calcified aortic valve stenosis (CAVS) is a progressive disease and nowadays, the cornerstone in diagnostics and follow-up is echocardiography. Cardiac biomarkers (such as cardiac troponins T and I and NT-pro-BNP) hold promise to fulfil a role in early recognition of complications concerning the aortic valve and decompensation. For this purpose, it is important to assess the normal biological variation (BV) of cardiac biomarkers in CAVS. The assessment of biological variation will contribute to a better understanding of fluctuation of cardiac biomarkers in subjects with stable CAVS. These data will improve monitoring of CAVS using cardiac biomarkers.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 25
Inclusion Criteria
- Clinically stable moderate aortic valve stenosis
- No evidence of acute cardiovascular disease
Exclusion Criteria
- Acute myocardial infarction in the last six months
- Pulmonary embolism in the last six months
- Hospitalisation for heart failure in the last six months
- Chronic kidney disease
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Arm && Interventions
Group Intervention Description Aortic valve stenosis No intervention Individuals with clinically stable moderate aortic valve stenosis
- Primary Outcome Measures
Name Time Method NT-pro-BNP One year Cardiac troponin I One year Cardiac troponin T One year
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Maastricht University Medical Center
🇳🇱Maastricht, Netherlands