Acute effects of growth hormone on cognitive functioning and related brain physiology in healthy subjects
- Conditions
- verouderingGrowth Hormone Deficiency (GHD)the effect of growth hormone10021112
- Registration Number
- NL-OMON35220
- Lead Sponsor
- niversiteit Utrecht
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 24
- male
- age; older than 55 years old
- BMI between 20 & 33
1. Any history of malignant disease.
2. Any history of pituitary or hypothalamic disease.
3. Any history of other central neurological disorders, including cerebrovascular infarctions, Parkinson's disease, multiple sclerosis, Alzheimer's disease.
4. Any active or recent (< 5years) psychiatric disease, including manic and depressive disorders or schizophrenia.
5. Severe cognitive deficits leading to incapacity to live independently.
6. Severe loss of vision (vision should be at least 0.5 in one eye), which is not corrected for (by glasses or lenses).
7. Any other internal condition necessitating chronic medication (subjects with well controlled hypertension, stable thyroid hormone substitution, stable hyperlipidaemia, osteoporosis, or chronic obstructive lung disease not necessitating systemic corticosteroids may be included; specific other situations can be judged by the researchers).
8. Alcohol consumption > 4 U/day.
9. Use of drugs (cannabis, cocaine, amphetamines etc.).
10. Use of medication that might affect cognitive function (e.g. benzodiazepines, antidepressants, antiepileptics, etc.).
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>The correlation between GH and cognitive functioning, and related brain<br /><br>physiology in healthy subjects. </p><br>
- Secondary Outcome Measures
Name Time Method <p>The correlation between cortisol/ testosterone and cognitive functioning, and<br /><br>related brain physiology in healthy subjects. </p><br>