A comprehensive research on identifying factors to predict transition to psychosis in participants at At-Risk Mental State by using Rorschach profiles and stress-related biomarkers in saliva.
Not Applicable
Recruiting
- Conditions
- schizophrenia, At-Risk Mental State
- Registration Number
- JPRN-UMIN000038573
- Lead Sponsor
- ara Medical University
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 168
Inclusion Criteria
Not provided
Exclusion Criteria
1)Those who have neurologic or medical neurologic or medical conditions as below: history of head trauma with loss of consciousness, chronic pulmonary disease, kidney disease, chronic liver disease, thyroid disease, active cancer, cerebrovascular disease, epilepsy, neurological disorder, substance related disorder, or mental retardation(IQ<70), obvious history of psychosis. 2)Those who are not seeking for help. 3)Those who suffer from autoimmune disease (SLE, hyperthyroidism: Graves' disease, ulcerative colitis, Crohn's disease). 4)Regular use of steroid or NSAID. 5)The attending physician decided that the patient was inappropriate to participate in the study.
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method (a)Rorschach test (b)Structured Interview for Prodromal Syndromes: SIPS (c)The Scale of Prodromal Symptoms: SOPS (d)Cortisol in saliva 2ml: alpha-Amylase, CRP (C-Reactive Protein), IL-6, IL-1-beta, in saliva.
- Secondary Outcome Measures
Name Time Method (a)the Scale to Assess Unawareness of Mental Disorder Japanese Version: SUMD-J (b)Subjective Well-being under Neuroleptic drug treatment Short form, Japanese version: SWNS-J (c)Positive and Negative Syndrome Scale: PANSS (d)The Brief Assessment of Cognition in Schizophrenia: BACS (e)Beck Depression Inventory-2: BDI-2 (f)Height, weight, smoking status