Magnetic Resonance Imaging Neuroanatomical Study of Patients with an Autism Spectrum Disorder, Their Relatives and Typically Developing Subjects.
Overview
- Phase
- N/A
- Intervention
- Not specified
- Conditions
- Autism Spectrum Disorder
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
- Enrollment
- 1000
- Locations
- 2
- Primary Endpoint
- 3DT1 MRI derived variables
- Status
- Recruiting
- Last Updated
- last year
Overview
Brief Summary
This project is structured around a central study called "Study of genetic factors involved in autism and related conditions ("Genes and Autism" study, sponsor: INSERM). This study explores clinical and genetic aspects of ASD (autism spectrum disorders) and is complemented with several ancillary studies (such as this one) which will use the data of the main study and will allow an extensive review of phenotypes associated with ASD.
In this ancillary study, we will go on the acquisition of anatomical, diffusion and functional MRI in subjects with ASD, relatives and controls. Our group has already performed several neuroanatomical studies of ASD. IWe recruited since 2010 more than 600 subjects (proponents, relatives and controls) to better understand the implication of brain abnormalities in ASD.
This study involves specialized teams in neuroiamging based at INSERM, NeuroSpin (CEA), Robert Debré Hospital (APHP) and Pasteur Institute
Our main objective is to identify structural, connectivity and functional peculiarities in subjects with ASD
Secondary objectives include:
- the identification of familial heritability patterns of ASD
- correlate data obtained in brain imaging with genetic data
- assess specificity and statistical reproducibility of the obtained results
Investigators
Eligibility Criteria
Inclusion Criteria
- •for patients:
- •being included in the main study "C16-89 - Study of genetic factors involved in ASD and related disorders"
- •having an ASD fulfilling DSM-5 diagnostic criteria (APA, 2012). Diagnosis will be done by a clinical expert, with the support of structured instruments (ADI-R, ADOS-2)
- •having at least 24 Months
- •being affiliated with the French health insurance
- •having signed the informed consent (by proposant or by legal tutors if the subject is \<18 or under legal custody)
- •for relatives
- •being included in the main study "C16-89 - Study of genetic factors involved in ASD and related disorders"
- •having at least 24 Months
- •being affiliated with the French health insurance
Exclusion Criteria
- •for patients: ASD diagnosis not confirmed by assessments after the inclusion
- •for all subjects: discovery of a counter indication to MRI during the exam (e.g. claustrophobia)
Outcomes
Primary Outcomes
3DT1 MRI derived variables
Time Frame: Day 0
Cortical folding Cortical thickness Cortical surface Cortical, white matter and subcortical volumes
Task based fMRI derived variables
Time Frame: Day 0
BOLD activation signals BOLD signal correlations
Resting state fMRI derived variables
Time Frame: Day 0
Whole-brain BOLD signal correlations
Diffusion MRI derived variables
Time Frame: Day 0
Fractional anisotropy and mean diffusivity NODDI derived variables
quantitative T1 and quantitative T2 MRI
Time Frame: Day 0
Myelin Water Fraction