Exercise Genes: Genomic Association With Exercise Reinforcement
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 88
- 试验地点
- 2
- 主要终点
- Relative reinforcing value (RRV) of physical activity
研究概览
简要总结
This study tests whether different physical activity patterns are linked an individual's genes.
详细描述
The investigators propose that an individual's genetics are one factor that may be associated with the motivating aspect or attractiveness of exercise and therefore the choice to exercise rather than be sedentary. They propose to study the association of the genomic signatures with the reinforcing (motivating) value of different types of exercise. This has never been investigated and may uncover underlying mechanisms that would help to understand individual differences in exercise motivation. The ultimate impact of this work is a greater number of Americans being physically active, meeting the United States Department of Agriculture (USDA) dietary guidelines for physical activity, and maintaining a healthy body weight. This study will be funded and undertaken at the Grand Forks Human Nutrition Research Center (GFHNRC). The purpose will be to assess genetic underpinnings of the motivating value of resistance and aerobic exercise, and to determine whether the motivating value of aerobic and resistance exercise are associated with usual participation in these modes of exercise.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Other
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 50 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •BMI within 18.5-35.0 kg/m2
- •Healthy enough to exercise
- •Active or inactive (not exercising at this time)
排除标准
- •Taking any drugs that affect energy expenditure (e.g., thyroid, glucose-lowering drugs)
- •Have gained or lost more than 5% of body weight over the past 6 months
- •Use tobacco
- •Pregnant or lactating or plan to become pregnant in the next 6 months
- •Have any health conditions that prevent the individual from safely exercising (e.g., cardiovascular, liver, endocrine, or pulmonary diseases)
研究组 & 干预措施
Aerobic Exercise vs Sedentary Option
Relative Reinforcing Value of aerobic exercise versus sedentary activity will be determined.
干预措施: Aerobic Exercise (Other)
Aerobic Exercise vs Sedentary Option
Relative Reinforcing Value of aerobic exercise versus sedentary activity will be determined.
干预措施: Sedentary Option (Other)
Resistance Exercise vs Sedentary Option
Relative Reinforcing Value of resistance exercise versus sedentary activity will be determined.
干预措施: Resistance Exercise (Other)
Resistance Exercise vs Sedentary Option
Relative Reinforcing Value of resistance exercise versus sedentary activity will be determined.
干预措施: Sedentary Option (Other)
结局指标
主要结局
Relative reinforcing value (RRV) of physical activity
时间窗: Week 0 (Cross-sectional)
RRV of physical activity will be assessed by evaluating the number of responses (mouse button presses) a subject is willing to complete to gain access to physical activity or a sedentary alternative.
Preference for intense physical activity and tolerance for exercise discomfort
时间窗: Week 0 (Cross-sectional)
Preference for intense physical activity and tolerance for exercise discomfort will be assessed by self-report questionnaire responses.
Genotypes of 23 small nucleotide polymorphisms (SNPs) previously identified to influence central dopamine release or uptake, reward, or physical activity
时间窗: Week 0 (Cross-sectional)
SNP genotyping will be performed on 3-5 ml samples of whole blood collected in ethylenediaminetetraacetic acid (EDTA)-containing tubes followed by allelic-discrimination analysis for the amplification and identification of each SNP.
次要结局
未报告次要终点