Open Versus Robotic-assisted Ventral Hernia Repair, Short and Long-term Outcome
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 56
- 试验地点
- 2
- 主要终点
- Length of stay (LOS)
研究概览
简要总结
In this randomized clinical trial, the investigators will compare the conventional open repair for hernia in the anterior abdominal wall with the robotic-assisted approach. 60 patients with midline abdominal wall defects will be randomized to either open or robotic-assisted surgery. The investigators will examine short and long-term complications through follow-up with clinical assessment as well as patient-reported outcome measures including pain, cosmetic appearance, and overall patient satisfaction. Furthermore, the investigators will study the difference in surgical stress response between the two methods measured from a variety of different biomarkers before and after the operation. A cost-effective analysis will be conducted for the robotic and open procedure.
详细描述
Ventral hernias occur in up to 25% of the population. They are diverse in severity ranging from small umbilical hernias to large abdominal wall defects that may result in loss of domain. Approximately one-third are incisional hernias. Incisional hernias are usually more complex due to complications from previous surgery. The procedure may be complicated as a result of intraabdominal bowel adhesions and adhesions within the hernial sac. These factors cause discomfort and may complicate the repair. Ventral hernias may be repaired either through a minimally invasive laparoscopic procedure or an open approach. The laparoscopic repair was introduced in the 1990s and in 2003 the first robotic-assisted procedure was described in a porcine model. In 2012 the first series of robotic repairs were reported in humans. Due to the superior flexibility of the robotic instruments, there is a substantial interest in harnessing the advantages of the robotic platform. Because robotic repair differs in several technical aspects from the open approach, it is important to determine whether the short and long-term results differ between the two procedures. Furthermore, it remains unresolved whether the robotic procedure is able to provide comparable outcomes to the open repair when assessed for quality-of-life outcome measures. These questions are important to address in order to determine the most appropriate surgical options for individual patients.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —(Adult, Older Adult)
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Clinical and radiologic diagnosis of midline ventral hernia
- •Eligible to surgery according to a preoperative anaesthetic assessment
- •Informed consent
- •Able to understand written and oral Danish language
排除标准
- •Incarcerated ventral hernia requiring emergency surgery
- •Pregnancy
- •Patients with chronic pain due to arthritis, migraine or other illness requiring regular intake of analgesics (paracetamol, NSAID, opiates etc).
- •Current cancer diagnosis
- •History of psychiatric or addictive disorder that prevents the patient from participating in the trial
- •Co-existing inflammatory disease
- •Co-existing immunological disease that requires medication of any kind
- •BMI >40 kg/m2
研究组 & 干预措施
Open repair
Open ventral hernia repair
干预措施: Open Hernia surgery (Procedure)
Robotic-assisted repair
Robotic-assisted ventral hernia repair
干预措施: Robotic Hernia surgery (Procedure)
结局指标
主要结局
Length of stay (LOS)
时间窗: Up until 3 months
The primary outcome measure will be assessed by reviewing the electronic patient journal system. The day of the procedure will be recorded as day 0
次要结局
- Operating time(Time from first incision to wound closure)
- Change in Surgical stress response (CRP)(measured at baseline preoperatively, 30 minutes after extubation, 120 minutes after extubation and on day 1 and 3.)
- Hernia defect size(Measured preoperatively)
- Intraoperative need of blood transfusion(From first incision until last suture has been placed)
- Change in surgical stress response (Interleukins)(Measured at baseline preoperatively and up until 120 minutes after extubation on day 1 and 3.)
- Treatment cost(From inclusion until 6 months postoperatively)
- Change in satisfaction and quality of life([Time Frame: From inclusion until 6 months after operation.])
