Inflammation-related Markers for the Prediction of Postoperative 1-year Mortality in Patients Undergoing Valvular Heart Surgery
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Patients Undergoing Valvular Heart Surgery
- Sponsor
- Yonsei University
- Enrollment
- 2046
- Locations
- 1
- Primary Endpoint
- 1-year mortality after valvular heart surgery
- Status
- Recruiting
- Last Updated
- 3 years ago
Overview
Brief Summary
The investigators aimed to develop a predictive model for mortality incorporating nutritional, inflammatory, and perioperative factors in patients undergoing valvular heart surgery. In this retrospective study, the investigators aimed to establish a comprehensive prediction model to predict the risk of 1-year mortality in valvular heart surgery patients through the identification of the inflammatory index most associated with 1-year mortality and developing a prognostic nomogram model incorporating perioperative risk factors with nutritional and inflammatory indices that would be verified by validation cohorts.
Investigators
Eligibility Criteria
Inclusion Criteria
- •patients who presented for surgery primarily due to valvular heart disease, including those who required concomitant coronary artery bypass surgery, aortic procedures, or other cardiac procedures.
Exclusion Criteria
- •patients aged \<18 years
- •undergoing transcatheter valve replacement, combined congenital heart surgery, or implantation of ventricular assist device, 3) lacking data required for calculating inflammatory indices, or 4) follow-up loss.
Outcomes
Primary Outcomes
1-year mortality after valvular heart surgery
Time Frame: 1 year after valvular heart surgery
Mortality at follow-up was analysed using time-to-event analysis, with survival time defined as the time from date of surgery until date of death.
Secondary Outcomes
- neutrophil-to-lymphocyte ratio (NLR), calculated as the number of neutrophils divided by the number of lymphocytes(within 1 month before surgery)
- monocyte-to-lymphocyte ratio (MLR), calculated as the number of monocytes divided by the number of lymphocytes(within 1 month before surgery)
- platelet-to-lymphocyte ratio (PLR), calculated as the number of platelets divided by the number of lymphocytes(within 1 month before surgery)