Effectiveness of different doses of dexmedetomidine on intraoperative hemodynamic profiles and postoperative pain in patients undergoing abdominal surgery: a randomized controlled trial

Phase 4

• Conditions: Circulatory System; Surgery; Anaesthesia

• Registration Number: PACTR202208813896934
• Lead Sponsor: Dilla University

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2022-08-01
• Last Update Posted: 29 May 2023

Recruitment & Eligibility

• Status: Pending
• Sex: All
• Target Recruitment: 99

Inclusion Criteria

ASA I and II
-age 18-65 yrs

Exclusion Criteria

-patients with a history of PONV, motion sickness, gastroparesis, bradycardia, atrioventricular block, and severe cardiac dysfunction, diabetes, hypertension, coronary heart disease, liver, and kidney function seriously damaged, chronic pain, chronic opioid users, upper respiratory tract infection, asthma, smoking

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Our primary endpoints will be to investigate the effect of different doses of dexmedetomidine infusion on hemodynamic response to critical incidences such as laryngoscopy, endotracheal intubation, surgical incision, and extubation in patients undergoing open abdominal surgery. A change in hemodynamic parameters (MAP, SBP, and HR) from baseline will be compared to the subsequent repeated measurements.

Secondary Outcome Measures

Name	Time	Method
Our secondary endpoints are to observe the effects on extubation time, post-operative sedation levels in the PACU, postoperative nausea and vomiting, postoperative pain score and analgesic requirements, time to first analgesic request, and occurrence of adverse effects. Postoperative analgesia therapy will be provided when patients complain of pain (request medication) or a numeric rating scale=of 4 is recorded. The analgesic drugs administered will be as per the hospital protocol.