Chemotherapy Monitoring With Breast Computed Tomography (CT)

Completed

• Conditions: Breast Cancer
• Interventions: Device: Dedicated breast computed tomography imaging

• Registration Number: NCT00808041
• Lead Sponsor: Emory University

Brief Summary

The purpose of this study is to determine if dedicated breast computed tomography can be used successfully to monitor tumor response in breast cancer patients undergoing neoadjuvant chemotherapy.

Detailed Description

Before undergoing surgery to remove the tumor, it is common for breast cancer patients to first undergo chemotherapy or hormonal therapy. The main goal of the therapy is to reduce the size of the tumor before it is removed. Unfortunately, therapy response varies a lot between patients. The development of an effective therapy response monitoring method could reduce the time that a patient undergoes ineffectual therapy or unnecessary therapy after complete response.

Dedicated breast computed tomography (or breast CT), a new way of imaging the breast, has been introduced in the last few years. Breast CT is an x-ray exam that uses 3D imaging to show the breast in its real three dimensional shape. Combined with the use of special chemicals called iodine contrast enhancement, breast CT can provide images of both the anatomy and the blood flow in the breast. We propose to use breast CT to carefully monitor the response to therapy of breast cancer patients undergoing therapy before surgery.

Basic Information
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Recruitment & Eligibility
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Study & Design
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Trial Locations

Study Timeline

• Study First Submitted: 2008-12-12
• Study First Submitted QC: 2008-12-12
• Study First Posted: 2008-12-15
• Study Start: 2009-07
• Primary Completion: 2012-09
• Status Verified: 2015-07
• Study Completion: 2015-07
• Last Update Submitted: 2015-07-21
• Last Update Posted: 2015-07-23

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Female
• Target Recruitment: 3

Inclusion Criteria

Not provided

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Exclusion Criteria

Not provided

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Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Treatment	Dedicated breast computed tomography imaging	Breast cancer patients undergoing hormonal therapy before surgery.

Primary Outcome Measures

Name	Time	Method
Tumor response	Mid-treatment and post-treatment completion

Trial Locations

Locations (1)

Emory University Winship Cancer Institute; 🇺🇸 Atlanta, Georgia, United States