Diabetes Bootcamp; Sport intervention in patients with diabetes type 2 and the association with the gut microbiota.
- Conditions
- DiabetesDiabetes Mellitus10018424
- Registration Number
- NL-OMON45040
- Lead Sponsor
- Vrije Universiteit Medisch Centrum
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 15
1. Patients with type 2 diabetes
2. Male or female (post-menopausal)
3. Age above 45 years and below 70 years
4. BMI >30 kg/m2
5. Metformine monotherapie (no insulin or other glucose lowering medication)
6. Stable medication use
7. Stable tension regulation (with or without medication)
8. Stable body weight during 6 months before enrolment in the study (<2 kg shifts)
9. Subjects should be able to give informed consent
10. HbA1c < 80 mmol/mol or < 8,6%
1. A history of cardiovascular event (Cerebrovascular event, myocardial infarction or pacemaker implantation)
2. Severe-very severe lung emphysema (GOLD stage III-IV)
3. Use of any antibiotics or proton pump inhibitor (PPI) in the past three months
4. Use of any other antidiabetic medication besides metformin (e.g. SU-derivates, insulin)
5. Use of a platelet inhibitor or cumarin derivate during
6. Subjects participated in a lifestyle programme in the past 6 months (diet or exercise)
7. Contraindications of iloprost (ilomedine®): increased risk of bleeding; severe coronary artery disease or instable AP; heart failure (NYHA class II-IV); severe arrhythmias; suspected left decompensation; hypersensitivity to the active substance or to any of the excipients
8. Contraindications of insulin(NovoRapid®): hypersensitivity to the active substance or to any of the excipients
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>Main study parameter/endpoint: change in gut microbiota composition</p><br>
- Secondary Outcome Measures
Name Time Method