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Diabetes Bootcamp; Sport intervention in patients with diabetes type 2 and the association with the gut microbiota.

Completed
Conditions
Diabetes
Diabetes Mellitus
10018424
Registration Number
NL-OMON45040
Lead Sponsor
Vrije Universiteit Medisch Centrum
Brief Summary

Not available

Detailed Description

Not available

Recruitment & Eligibility

Status
Completed
Sex
Not specified
Target Recruitment
15
Inclusion Criteria

1. Patients with type 2 diabetes
2. Male or female (post-menopausal)
3. Age above 45 years and below 70 years
4. BMI >30 kg/m2
5. Metformine monotherapie (no insulin or other glucose lowering medication)
6. Stable medication use
7. Stable tension regulation (with or without medication)
8. Stable body weight during 6 months before enrolment in the study (<2 kg shifts)
9. Subjects should be able to give informed consent
10. HbA1c < 80 mmol/mol or < 8,6%

Exclusion Criteria

1. A history of cardiovascular event (Cerebrovascular event, myocardial infarction or pacemaker implantation)
2. Severe-very severe lung emphysema (GOLD stage III-IV)
3. Use of any antibiotics or proton pump inhibitor (PPI) in the past three months
4. Use of any other antidiabetic medication besides metformin (e.g. SU-derivates, insulin)
5. Use of a platelet inhibitor or cumarin derivate during
6. Subjects participated in a lifestyle programme in the past 6 months (diet or exercise)
7. Contraindications of iloprost (ilomedine®): increased risk of bleeding; severe coronary artery disease or instable AP; heart failure (NYHA class II-IV); severe arrhythmias; suspected left decompensation; hypersensitivity to the active substance or to any of the excipients
8. Contraindications of insulin(NovoRapid®): hypersensitivity to the active substance or to any of the excipients

Study & Design

Study Type
Interventional
Study Design
Not specified
Primary Outcome Measures
NameTimeMethod
<p>Main study parameter/endpoint: change in gut microbiota composition</p><br>
Secondary Outcome Measures
NameTimeMethod
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