To study the efficacy of high dose steroids and compare it with no steroids in patients with severe alcoholic hepatitis with is a type of alcohol associated liver disease
Phase 3
- Conditions
- Health Condition 1: K701- Alcoholic hepatitis
- Registration Number
- CTRI/2024/06/069359
- Lead Sponsor
- Dr Prachis Ashdhir
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Yet Recruiting
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
All the patients greater than 18years of age with diagnosed Severe Alcoholic hepatitis with mDF (Maddrey’s Discriminant function) greater than 32 with or without underlying cirrhosis are included.
Exclusion Criteria
Patients with evidence of active GI bleed,active Infections/ Sepsis,patients with mDF greater than 90,patients with encephalopathy,patients with AKI/ Renal failure,patients requiring inotropic support,not willing to give consent.presence of other liver diseases and pregnant women.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method To identify and compare the survival of patients on standard of care treatment and pulse dose steroids.Timepoint: The patients and the outcomes will be assessed at 4th day, at 2 weeks, at 4 weeks and at 6 weeks.
- Secondary Outcome Measures
Name Time Method To identify the appropriate dose and side effects profile of patients on pulse dose steroids.Timepoint: 6weeks