NCT00682812已完成不适用
Significance of the High-risk Hpv Viral Load
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 149
- 试验地点
- 2
- 主要终点
- Estimate the meaning of a viral load raised in HPV oncogenic
研究概览
简要总结
The aim of this study is to evaluate the significance of an elevated high-risk HPV (HR-HPV) viral load.
详细描述
We will particularly evaluate if the HR-HPV viral load:
- Is correlated to the transcription of the genes of the oncoproteins E6 and E7
- Is predictive of the integration of the virus in infected cells
- Is predictive of the presence of HPV in patients' blood
- Influences the local and systemic immunologic response
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Other
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •The women consulting for the therapeutic care (by hysterectomy or conization) of a LIEHG or a cervical cancer (carcinoma epidermoid or adenocarcinoma) confirmed by the anatomopathologique analysis of a preoperative cervical biopsy.
- •The women having a normal cervix consulting for the surgical care by hysterectomy of a good-hearted pathology of the womb. The normality of the cervix will be confirmed by the anatomopathologique analysis of the detail of hysterectomy
- •The patients participating in this study will have to be of more than 18 years old. All the subjects will be profitable of a regime of Social Security.
排除标准
- •The patients having a LIEBG
- •The patients incapable to receive the information enlightened on the progress and the objectives of the study
- •The patients not having signed enlightened assent
结局指标
主要结局
Estimate the meaning of a viral load raised in HPV oncogenic
时间窗: 36 months
次要结局
- Estimate the correlation between the viral load in HPV oncogenic and the integration of the viral genome in that of the infected cells(36 months)
- To estimate the correlation enters the vorale load of the HPV oncogenic and the severity of the cervical hurt(36 months)
- Estimate the correlation between the viral load of the HPV oncogenic and the level of transcription of the genes coding for oncoproteines E6 and E7(36 months)
- Estimate the correlation between a viral load raised in HPV oncogenic and a presence of HPV in the circulating blood of the infected patients(36 months)
研究者
研究点 (2)
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