Postoperative Recovery After Cardiac Surgery A Randomised Controlled Trial of High-dose Opioid Versus Opioid-sparing Anaesthesia
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Cardiac Surgery Patients
- Sponsor
- Chinese Academy of Medical Sciences, Fuwai Hospital
- Enrollment
- 80
- Locations
- 1
- Primary Endpoint
- QoR-15 at 24h
- Status
- Enrolling By Invitation
- Last Updated
- last year
Overview
Brief Summary
BACKGROUND In cardiac surgery, high-dose opioid contributes to adverse events associated with poor postoperative outcomes. There is growing evidence that nerve block-based multi-modal anesthesia protocols may reduce intraoperative opioid consumption without compromising analgesia management and consequently improve patient's early postoperative recovery.
OBJECTIVE To determine whether opioid-sparing anaesthesia based on ultrasound-guided nerve block could improve early postoperative recovery after cardiac surgery.
DESIGN A randomised controlled trial. SETTING A tertiary hospital. PATIENTS Eighty patients aged 45 to 70 years undergoing cardiac surgery were enrolled. Key exclusion criteria included contraindication to interventions or drugs and a history of chronic pain or chronic opioid use.
INTERVENTIONS Eligible patients were randomised at a 1:1 ratio to receive either opioid-sparing anaesthesia based on ultrasound-guided nerve block (intervention group) or opioid-based anaesthesia (control group).
MAIN OUTCOME MEASURES The primary outcome was the global score of the 15-item Quality of Recovery (QoR-15) questionnaire at 24h after surgery. Secondary outcomes included QoR-15 at 72h after surgery, postoperative pain score, the incidence of postoperative adverse events and chronic pain. Other outcomes included endotracheal intubation duration, length of hospitalization, and hospital costs.
Investigators
Yan Fuxia
Principal Investigator
Chinese Academy of Medical Sciences, Fuwai Hospital
Eligibility Criteria
Inclusion Criteria
- •Male or female adult patients aged 45 to 70 years, awaiting elective cardiac surgery, and American Society of Anaesthesiologists physical status classes II or III were eligible.
Exclusion Criteria
- •contraindications to punctual or local anesthetic drugs, a history of chronic pain or chronic opioid use, and an inability to communicate or refuse to enroll.
Outcomes
Primary Outcomes
QoR-15 at 24h
Time Frame: at 24 hours after surgery
the global score of the 15-item Quality of Recovery (QoR-15) questionnaire at 24h after surgery
Secondary Outcomes
- Number rating score (NRS)(NRS at 24 hours and 72 hours after surgery)
- postoperative adverse events(during hospitalization, an average of 2 weeks, assessed up to 30 days)
- chronic pain(at 3 months after surgery)
- QoR-15 at 72h(QoR-15 at 72 hours after surgery)