Utilizing Long-read Sequencing to Investigate the EGFR Landscape of EGFR Positive Lung Cancer Patients
- Conditions
- Lung Cancer - Non Small CellEGFR Exon 19 Deletion Mutation
- Registration Number
- NCT06659458
- Lead Sponsor
- Our Lady of the Lake Hospital
- Brief Summary
EGFR gene mutations are some of the most commonly occurring mutations in non-small cell lung cancer. Investigators have developed a DNA instability model that estimates a risk score to assess the likelihood of an individual acquiring a cancer-linked mutation. The aim of this study is to collect blood from both those diagnosed with EGFR positive lung cancer and healthy individuals, evaluate their gene sequence surrounding the EGFR landscape and use the cancer positive and healthy sequences to validate the risk assessment model, which may one day be used to provide insight on susceptibility of getting EGFR positive lung cancer or potentially other cancer types.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- RECRUITING
- Sex
- Female
- Target Recruitment
- 20
- 18-100 years old
- Biologically born female
- Diagnosed with EGFR positive lung cancer (Arm 1-Cancer group)
- No cancer diagnosis (Arm 2-health control)
- less than 18 years of age
- Biologically born male
- Incarcerated at the time of participation
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Differences in DNA sequence of EGFR gene From enrollment to end of data analysis at 6 months Subjects who have EGFR positive lung cancer will have their gene sequence compared to those that are EGFR negative and do not have lung cancer to look for differences in the sequence.
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Our Lady of the Lake Regional Medical Center
🇺🇸Baton Rouge, Louisiana, United States