Menopausal Impact on Skin Aging Among Egyptian Women: a Comparative Cross-sectional Study
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 入组人数
- 500
- 主要终点
- Clinical skin aging severity using Glogau Photoaging Scale
研究概览
简要总结
The goal of this study is to understand how menopause affects skin aging in Egyptian women between the ages of 40 and 60.
The main question the study wants to answer is:
Does menopause cause any changes in how the skin ages?
To find out, the participants will be divided into two groups based on their menstrual history:
- Women who have not yet gone through menopause (premenopausal)
- Women who have already gone through menopause (postmenopausal) A researcher will examine the skin of women in both groups to look for signs of aging. Then, the results will be compared to see if there are any differences between the two groups.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 40 Years 至 60 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •Females aged 40 to 60 years
- •Egyptian nationality or residency
- •Ability to provide informed consent
- •Classified as either:
- •Premenopausal (still menstruating regularly)
- •Postmenopausal (no menstruation for ≥12 months)
排除标准
- •Menopausal transition (Perimenopausal women
- •Menopause induced by hysterectomy
- •History of hormone therapy in the past 6 months
- •Active dermatological conditions affecting the face (e.g. eczema, psoriasis)
- •Use of anti-aging skin treatments (e.g. laser, fillers, retinoids)
- •Severe chronic illnesses that may affect skin condition
结局指标
主要结局
Clinical skin aging severity using Glogau Photoaging Scale
时间窗: Assessed once at baseline during participant's visit
The Glogau Photoaging Scale will be used for evaluation. Facial assessment will be conducted both at rest and during facial animation to observe dynamic changes. Participant will be categorized into 4 types or grades where type 1 is mild skin aging and type 4 is severe skin aging
Dermoscopic skin aging score using the dermoscopic photoaging assessment scale
时间窗: Assessed once at baseline during participant 's visit
this scale is used to assess facial skin aging. The face will be divided into four regions: the forehead, right cheek, left cheek, and chin. Each region will be examined for the presence of the following features: yellowish discoloration, yellow papules, white linear areas indicating skin atrophy, lentigines, hypo- or hyperpigmented macules, telangiectasia, actinic keratoses, senile comedones, deep wrinkles, superficial wrinkles, and criss-cross wrinkles. Scoring follows a binary (yes/no) approach, where the presence of a given feature in any of the four regions scores one point, yielding a total possible score ranging from 0 to 44. a higher score means worse outcome.
次要结局
- Prevalence of specific clinical and dermoscopic aging features(Recorded during clinical and dermoscopic assessment at baseline)
- Correlation between menopausal status and severity of skin aging(Assessed once at baseline during participant's visit based on menopausal history and skin aging scores)
- Correlation between menopausal duration and skin aging(Menopausal duration collected via history at baseline; skin aging assessed at baseline)
研究者
Amal Abdulhameed Mostafa
Principal investigator
Sohag University