Antidepressant Effect of Theta-Burst rTMS
- Conditions
- Major Depression
- Registration Number
- NCT00515658
- Lead Sponsor
- Rambam Health Care Campus
- Brief Summary
The aim of this study is to evaluate the safety and efficacy of theta-burst rTMS in patients with major depression. Patients will be randomized to receive ether left-sided intermittent theta-burst rTMS or rigt-sided continuous theta-burst rTMS or sham theta-burst rTMS over two weeks period with an option for an additional two weeks period, depending on treatment response. Clinical assessments will be performed weekly by the Hamilton depression rating scale. In addition, standard neurophysiological assessment of cortical excitability will be done.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- Not specified
- Major depressive episode (DSM IV criteria).
- Informed consent.
- Age: 18-70.
- Suicidality
- Psychosis
- Pacemaker
- Cardiac arrythmia
- seizure disorder
- implantable metal devices
- PNS and CNS disorders
- any other contraindications as specified in safety guidelines for rTMS (Wassermenn, 1998).
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method
Related Research Topics
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Trial Locations
- Locations (1)
Rambam Medical Center
🇮🇱Haifa, Israel
Rambam Medical Center🇮🇱Haifa, IsraelEhud Klein, MDPrincipal InvestigatorAndrei Chistyakov, PhDSub Investigator