NCT05926492招募中2 期
A Prospective, Multicenter, Non-randomized Controlled Clinical Study of Surufatinib Combined With Chemotherapy as Neoadjuvant Treatment in Patients With Osteosarcoma
Second Affiliated Hospital, School of Medicine, Zhejiang University1 个研究点 分布在 1 个国家目标入组 160 人开始时间: 2024年1月9日最近更新:
适应症
干预措施
相关药物
试验速览
- 阶段
- 2 期
- 状态
- 招募中
- 发起方
- 入组人数
- 160
- 试验地点
- 1
- 主要终点
- Tumor cell necrosis rate (TCNR)
研究概览
简要总结
This phase II study aims to explore the tumor necrosis rate in osteosarcoma patients treated with a neoadjuvant regimen of surufatinib combined with chemotherapy.
详细描述
Surufatinib is a potent inhibitor of colony-stimulating factor 1 receptor（CSF-1R）, which shows a promising tumor inhibition effect on sarcoma. This is a prospective, multicenter, controlled phase II study to explore the efficacy and safety of surufatinib combined with chemotherapy in neoadjuvant treatment of osteosarcoma. In this study, 160 patients were enrolled into the following treatment groups with a 1:1 ratio: (1) Surufatinib + chemotherapy group (N=80) (2) control group: chemotherapy group (N=80); A 30-day treatment cycle was performed, the efficacy was evaluated after 2 cycles of neoadjuvant therapy. The primary endpoints were tumor necrosis rate, and secondary endpoints were 1-year progression-free survival (PFS) and drug safety.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 2 Years 至 70 Years（Child, Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Have fully understood the study and voluntarily signed the informed consent;
- •Age from 2 to 70 years old (inclusive), both male and female;
- •histologically or cytologically confirmed diagnosis of primary bone tumor
- •having at least one measurable lesion (RECIST 1.1);
- •The patient has not been treated before (including any chemotherapy, targeting, immune and other drugs);
- •The functions of major organs and bone marrow are basically normal;
- •ECOG performance status 0 or 1 (PS 0-2 points for amputees);
- •Expected survival ≥12 weeks;
- •Blood test (without blood transfusion within 14 days) 1) Neutrophil absolute value ≥1.5×109/L, platelets ≥100×109/L, hemoglobin concentration ≥9g/dL); 2) Liver function test (aspartate aminotransferase and glutamic aminotransferase ≤2.5×ULN, total bilirubin ≤1.5×ULN; In case of liver metastasis, AST and ALT≤5×ULN); 3) Renal function (serum creatinine ≤1.5×ULN, creatinine clearance (CCr)≥60ml/min);
- •Fertile male or female patients voluntarily used effective contraceptive methods, such as double barrier methods, condoms, oral or injectable contraceptives, intrauterine devices, etc., during the study period and within 6 months of the last study dose. All female patients will be considered fertile unless the female patient has undergone natural menopause, artificial menopause or sterilization (such as hysterectomy, bilateral adnexectomy or radiation of the ovary).
排除标准
- •Patients who have previously received chemotherapy drugs, surufatinib, or other antiangiogenic agents;
- •Received approved or under development systematic anti-tumor therapy within 4 weeks before enrollment, including chemotherapy, radical radiotherapy, biological immunotherapy, targeted therapy, etc.;
- •Received any surgery or invasive treatment or operation (except intravenous catheterization, puncture drainage, etc.) within 4 weeks before enrollment;
- •International Standardized Ratio (INR)> 1.5 or partially activated prothrombin time (APTT) > 1.5×ULN;
- •The investigator identified clinically significant electrolyte abnormalities;
- •The patient currently has hypertension that cannot be controlled by drugs, as follows: systolic blood pressure ≥140 mmHg and/or diastolic blood pressure ≥90 mmHg;
- •Unsatisfactory blood glucose control (FBG > 10 mmol/L);
- •The patient has any current disease or condition that affects the absorption of the drug, or the patient cannot take surufatinib orally;
- •The patient currently has gastrointestinal diseases such as active gastric and duodenal ulcers, ulcerative colitis, or active bleeding from unresected tumors, or other conditions determined by researchers that may cause gastrointestinal bleeding or perforation;
- •Patients with evidence or history of significant bleeding tendency within 3 months prior to enrollment (bleeding >30 mL within 3 months , hematemesis, stool, stool blood), hemoptysis ( > 5 mL of fresh blood within 4 weeks) or had a thromboembolic event (including stroke events and/or transient ischemic attacks) within 12 months;
- •Clinically significant cardiovascular disease, including but not limited to the following: acute myocardial infarction, severe/unstable angina pectoris, or coronary artery bypass grafting within 6 months prior to enrollment; New York Heart Association (NYHA) Grades for Congestive Heart Failure was > level 2; Ventricular arrhythmias requiring medical treatment; LVEF (Left ventricular Ejection Fraction) < 50%;
- •Have had other malignancies within the past 5 years, except basal cell or squamous cell carcinoma of the skin after radical surgery, or carcinoma in situ of the cervix;
- •Active or uncontrolled severe infection; 1) Known human immunodeficiency virus (HIV) infection; 2) Known history of clinically significant liver disease, including viral hepatitis [active HBV infection, i.e., HBV DNA positive (> 1×104 copies /mL or > 2000 IU/ml) must be excluded for known hepatitis B virus (HBV) carriers; 3) Known hepatitis C virus infection (HCV) and HCV RNA positive (> 1×103 copies /mL), or other hepatitis, cirrhosis;
- •The patient has current central nervous system (CNS) metastases or previous brain metastases;
- •Patients with persistent toxicity due to any previous antitumor therapy that has not returned to ≤ grade 2, but with alopecia or lymphocytopenia of any grade are admitted to this study;
- •Women who are pregnant (positive pregnancy test before medication) or breastfeeding;
- •Received blood transfusion therapy, blood products and hematopoietic factors, such as albumin and granulocyte colony-stimulating factor (G-CSF), within 14 days before enrollment;
- •Any other medical condition, clinically significant metabolic abnormality, physical abnormality or laboratory abnormality, which, in the investigator's judgment, reasonably suspects that the patient has a medical condition or condition that is not suitable for the use of the investigational drug (such as having seizures and requiring treatment), or which would affect the interpretation of the study results or place the patient at high risk;
- •Urine routine indicated urinary protein ≥2+, and 24-hour urinary protein quantification >1.0g.
研究组 & 干预措施
Surufatinib plus chemotherapy
Experimental
Patients were to receive surufatinib plus chemotherapy every 30 days as neoadjuvant treatment. After receiving 2 cycles of treatment, patients will be evaluated for tumor necrosis rate.
干预措施: Surufatinib plus chemotherapy (Drug)
Chemotherapy
Active Comparator
Patients were to receive chemotherapy every 30 days as neoadjuvant treatment. After receiving 2 cycles of treatment, patients will be evaluated for tumor necrosis rate.
干预措施: Chemotherapy (Drug)
结局指标
主要结局
Tumor cell necrosis rate (TCNR)
时间窗: 12 months
The percentage of patients with tumor cell necrosis \> 90% was assessed according to Huvos
次要结局
- All adverse event/Serious adverse event that occurred during the study period according to CTCAE 5.0(24 months)
- 1 year Progression-free survival (PFS) rate(1 year)
研究者
研究点 (1)
Loading locations...
相似试验
已完成
2 期
Phase II Open Label, Non-randomized Study of Sorafenib and Everolimus in Relapsed and Non-resectable OsteosarcomaMetastatic OsteosarcomaRelapsed OsteosarcomaNCT01804374Italian Sarcoma Group38
已完成
3 期
Osteosarcoma Study #2: A Randomized Trial of Pre-Surgical Chemotherapy vs. Immediate Surgery and Adjuvant Chemotherapy in the Treatment of Non-Metastatic Osteosarcoma. A Pediatric Oncology Group Phase III StudyOsteosarcomaNCT00001217National Cancer Institute (NCI)260
已完成
2 期
A Phase II Study Evaluating Efficacy and Safety of Regorafenib in Patients With Metastatic Bone SarcomasEwing SarcomasChondrosarcomasOsteosarcomasChondromaCIC-Rearranged SarcomaNCT02389244UNICANCER163
已完成
不适用
Grade 2 Chondrosarcoma Treated by Intralesional Curettage: Follow-up vs ResectionChondrosarcoma, Grade 2NCT06714773IRCCS Azienda Ospedaliero-Universitaria di Bologna62
招募中
不适用
Radiotherapy or Observation of Liver Metastases in Small Cell Lung CancerComplications RadiotherapyNCT05150145Guizhou Medical University66