Diagnostic Accuracy of Multislice CT Angiography for Acute Chest Pain - Assessment of Chest Pain Utilizing a Triple Rule Out Evaluation With Computed Tomography (ACUTE CT) Trial
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 102
- 试验地点
- 1
- 主要终点
- Diagnostic accuracy of CT compared to standard of care evaluation
研究概览
简要总结
The ACUTE CT trial is designed to test whether the assessment of chest structures by high-resolution multislice computed tomography (CT) provides equivalent diagnostic accuracy for patient with acute chest pain or other potential cardiac symptoms as compared to a standard of care evaluation.
详细描述
Adults at low to intermediate risk of acute coronary syndrome who present to the Emergency Department with symptoms suggestive of cardiac ischemia will undergo a blinded cardiac CT followed by a standard of care (SOC) strategy. Significant coronary artery disease on CT (coronary stenosis >50%) will be compared to an adjudicated diagnosis derived from clinical data and other diagnostic tests based on the SOC strategy. Costs for the SOC evaluation will be collected and compared to a CT-based evaluation. Patients will be followed for 3 years after enrollment to evaluate prognosis.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 30 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Low to intermediate risk of angina with a TIMI ACS Risk Score ≤ 4
- •chest pain or other symptoms suggestive of ACS within 24 hours
- •male ≥30 years or female ≥45 years old
- •at least one cardiac risk factor
- •no obvious cause for symptoms.
排除标准
- •known CAD
- •ST segment elevation, new left bundle branch block or dynamic ECG changes
- •creatinine ≥1.8 g/dL
- •pregnant or lactating female
- •hemodynamic or respiratory instability
- •ongoing bronchospasm
- •known iodinated contrast allergy
- •atrial fibrillation or irregular heart rate
结局指标
主要结局
Diagnostic accuracy of CT compared to standard of care evaluation
时间窗: 3 months
次要结局
- Cost savings of CT-based evaluation compared to the standard of care evaluation(3 months)
研究者
Kelley Branch
Assistant Professor
University of Washington