Ovarian Reserve and Embryo Implantation

Completed

• Conditions: IVF; Ovarian Reserve
• Interventions: Other: no intervention. observational study

• Registration Number: NCT03989921
• Lead Sponsor: Centre Hospitalier Universitaire de Nīmes

Brief Summary

Compare, in young patients with In vitro fertilization (IVF), the rate of embryo implantation by early culture transfer (J2-J3) between 2 groups of patients: "normo responders" vs. "poor responders".

Detailed Description

Not available

Study Timeline

• Study Start: 2018-11-29
• Primary Completion: 2019-04-30
• Study Completion: 2019-04-30
• Status Verified: 2019-06
• Study First Submitted: 2019-06-13
• Study First Submitted QC: 2019-06-17
• Last Update Submitted: 2019-06-17
• Study First Posted: 2019-06-18
• Last Update Posted: 2019-06-18

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Female
• Target Recruitment: 598

Inclusion Criteria

• IVF patient managed with or without ICSI between 01/01/2014 and 30/06/2015 in one of the two study centres
• Age < 35 years old
• Fresh transfer of at least one embryo between D2 and D6
• patients who have already received one or more transfer attempts.

Exclusion Criteria

• No fresh transfer (Freeze All, segmentation failure, stimulation failure)
• Double successive embryo transfer (e. g. J3-J5). We did not retain these cases because if only one of the 2 embryos is implanted, it is not possible to know which transfer it corresponds to.
• Maternal serum FSH determination < 4 IU/ml at D3 in the baseline balance sheet (hypogonadotropic hypogonadism)

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
normo responders	no intervention. observational study	that have an AMH dosage greater than or equal to 1.2 ng/mL
poor responders	no intervention. observational study	with a dosage of less than 1.2 ng/mL

Primary Outcome Measures

Name	Time	Method
The embryo implantation rate at 5 weeks after transfer is defined by the presence of an embryo with objective cardiac activity by ultrasound	5weeks	The embryo implantation rate corresponds to the number of embryos with cardiac activity found on the number of embryos transferred

Trial Locations

Locations (1)

CHUNimes; 🇫🇷 Nîmes, France