Social Cognition in Disruptive behavior and Aggressio

Recruiting

Conditions: disruptief gedrag en agressie
conduct disorder
oppositional defiant disorder
10009841

Registration Number: NL-OMON49770

Lead Sponsor: Accare

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Recruiting

Sex: Not specified

Target Recruitment: 105

Inclusion Criteria

• Aged 12-17 at inclusion
• Ability to comprehend and speak Dutch
• Deemed reliable and compliant with the study protocol
• Be right-handed

Those with behavioral problems must also meet the additional criteria:
• Presence of clinically significant behavioral problems as defined by T > 63
on the externalizing subscale of the Child Behavior Checklist (CBCL) or the
Youth Self-Report (YSR). The externalizing dimension of the CBCL includes the
rule-breaking behavior and aggressive behavior syndrome subscales (not ADHD).
To ensure we also include youth with more severe behavioral (rule-breaking)
problems, we aim to have at least 50% of participants with clinically
significant behavioral problems scoring T > 70 on the rule-breaking subscale of
the CBCL and/or YSR.
• At least 2 weeks of stable treatment /medication

Exclusion Criteria

• Intellectual disability (IQ < 70) based on available IQ measure or the
clinical opinion of the
investigator (taking into account relevant psychosocial information,
e.g. educational level)
• History of or current head injury
• History of neurological disorders
• A known lifetime history of epilepsy
• A known lifetime history of psychotic and bipolar disorder, or severe current
mental state according to the impression of the researcher (such as depression)

Potential healthy control subjects who meet any of the following additional
criteria will be excluded from participation in this study if they have:
• A parent or self-reported diagnosis of a psychiatric disorder
• T-scores in the borderline or clinical range on the externalizing (T >= 60),
rule-breaking (T >= 65) or aggressive behavior (T >= 65) subscales of the CBCL or
YSR.
• No stable use of psychotropic medication in the past four weeks

Study & Design

Study Type: Observational non invasive

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Behavioral: Empathy (score on EMQUE-CA questionnaire)<br /><br>Cognitive: Working memory (SWM accuracy)<br /><br>QEEG: resting state frontal alpha asymmetry<br /><br>ERPS: N170 during the emotion recognition task</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Behavioral: Questionnaires on temperamental factors, emotional regulation,<br /><br>social reward, normative beliefs about aggression, environmental sensitivity,<br /><br>autism traits, sensory processing, strengths and difficulties<br /><br>Cognitive: Accuracy and reaction times on tasks measuring reaction time, visual<br /><br>matching, sustained attention, number of stages completed on the planning<br /><br>task, and accuracy and reaction times on the EEG tasks measuring emotion<br /><br>recognition, emotional interference, social approach/avoidance and theory of<br /><br>mind<br /><br>QEEG: resting state frontal theta activity and theta/beta ratio<br /><br>ERPS: N170 and LPP during emotional interference, social approach-avoidance<br /><br>and theory of mind </p><br>