Prospective Ultrasonographic and Magnetic Resonance Imaging (MRI) Assessment of General and Brain Fetal Development in Offspring of Schizophrenic Patients
试验速览
- 阶段
- 不适用
- 入组人数
- 80
- 试验地点
- 8
- 主要终点
- Brain morphological changes between groups
研究概览
简要总结
Schizophrenia is a common disorder with a lifetime prevalence of about 1%.Genetic studies strongly suggest a genetic component to the inheritance of schizophrenia. Structural neuroimaging studies have provided consistent evidence for brain abnormalities in schizophrenia. The timing of brain abnormalities in schizophrenia has not been determined yet.
The investigators hypothesize that brain structural changes can be detected in neonatal life. The investigators hypothesize that offspring of schizophrenic patients will have higher rates of brain structural changes in the neonatal period. The investigators propose to study early development of fetuses in offspring of patients with schizophrenia. The study is a multi-center prospective trial.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Screening
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 60 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •Pregnant women who carry an offspring of a schizophrenia patient: whether the mother, the father or both suffer from schizophrenia.
排除标准
- •Alcohol or drug abuse of pregnant woman
- •Past history or present occurrence of major neurologic or somatic illness
- •Genetic disease
- •Other psychiatric disorders other than schizophrenia such as Mental retardation
- •Bipolar Disorder and Delusional Disorder
结局指标
主要结局
Brain morphological changes between groups
时间窗: 2 years
Both MRI scans and US scans will be compared between the groups, assessing brain morphological and volumetric differences .
次要结局
未报告次要终点