Schizophrenia Imaging

Not Applicable

• Conditions: Foetal Differences Between Healthy and Schizophernic Parents

• Registration Number: NCT01655472
• Lead Sponsor: Tel-Aviv Sourasky Medical Center

Brief Summary

Schizophrenia is a common disorder with a lifetime prevalence of about 1%.Genetic studies strongly suggest a genetic component to the inheritance of schizophrenia. Structural neuroimaging studies have provided consistent evidence for brain abnormalities in schizophrenia. The timing of brain abnormalities in schizophrenia has not been determined yet.

The investigators hypothesize that brain structural changes can be detected in neonatal life. The investigators hypothesize that offspring of schizophrenic patients will have higher rates of brain structural changes in the neonatal period. The investigators propose to study early development of fetuses in offspring of patients with schizophrenia. The study is a multi-center prospective trial.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2012-06-30
• Status Verified: 2012-07
• Study Start: 2012-07
• Study First Submitted QC: 2012-07-31
• Last Update Submitted: 2012-07-31
• Study First Posted: 2012-08-01
• Last Update Posted: 2012-08-01
• Primary Completion: 2014-07
• Study Completion: 2015-07

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: Female
• Target Recruitment: 80

Inclusion Criteria

• Pregnant women who carry an offspring of a schizophrenia patient: whether the mother, the father or both suffer from schizophrenia.

Exclusion Criteria

• Alcohol or drug abuse of pregnant woman
• Past history or present occurrence of major neurologic or somatic illness
• Genetic disease
• Other psychiatric disorders other than schizophrenia such as Mental retardation
• Bipolar Disorder and Delusional Disorder

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Primary Outcome Measures

Name	Time	Method
Brain morphological changes between groups	2 years	Both MRI scans and US scans will be compared between the groups, assessing brain morphological and volumetric differences .

Trial Locations

Locations (8)

Geha mental health centre; 🇮🇱 Petah Tiqwa, Israel

Chaim Sheba medical centre; 🇮🇱 Tel Hashomer, Israel

Brill outpatient clinic; 🇮🇱 Tel Aviv, Israel

Abarbanel Mental Health Centre; 🇮🇱 Bat Yam, Israel

Beer Yaacov Mental health Centre; 🇮🇱 Beer Yaakov, Israel

Shalvata mental health centre; 🇮🇱 Hod Hasharon, Israel

Edith Wolfson Medical Centre; 🇮🇱 Holon, Israel

Sourasky Medical Centre; 🇮🇱 Tel Aviv, Israel