Effectiveness and safety of Yizhiqingxin Formula in treating patients with vascular dementia(stasis toxin syndrome)

Not Applicable

Not yet recruiting

• Conditions: Vascular Dementia

• Registration Number: ITMCTR2200005592
• Lead Sponsor: Xiyuan Hospital,China Academy of Traditional Chinese Medicine

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 2023-02-20

Recruitment & Eligibility

• Status: Pending
• Sex: All
• Target Recruitment: Not specified

Inclusion Criteria

Diagnostic criteria:
? American Psychiatric Association Diagnostic Manual and Statistical Manual of Mental Disorders Standard (DSM-IV);
?2002 Chinese Medical Association Neurology Branch Draft Diagnostic Criteria for Vascular Dementia.

?Age =45 years old and =75 years old, both male and female; women should be postmenopausal women who are infertile.
?Meet the above diagnostic criteria for dementia, VD diagnostic criteria and TCM syndrome diagnostic criteria, and the course of dementia is more than 3 months.
? The degree of CDR dementia was assessed as mild and moderate dementia (CDR=1.0, 2.0).
? Mini-Mental State Examination Scale (MMSE) = 26 points, = 10 points.
?HIS points = 7 points.
? Volunteers and signed informed consent.
? Have a correct understanding of the significance of drug research, and have good compliance with the observation and evaluation of researchers.
? Have a certain degree of education, can read simple newspaper articles and write simple small articles in the past.

Exclusion Criteria

? Alzheimer's disease patients with HIS score =4 points and mixed dementia patients with 5-6 points.
? Patients with dementia and depression were excluded.
? Patients with CDR=3.0.
? Dementia patients after cerebral hemorrhage or large cortical infarction.
? Those with severe neurological deficits.
? Patients with severe heart, liver and kidney function.
? Patients who have used any history of drugs that may affect cognitive function in the past 3 months.

Study & Design

• Study Type: Interventional study
• Study Design: Not specified