Assessment of Protein requirements in malnourished school-aged South Indian children.

Not Applicable

Completed

• Registration Number: CTRI/2018/03/012659
• Lead Sponsor: Dr Anura V Kurpad

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Completion: 2018-02-21
• Last Update Posted: 24 November 2021

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 18

Inclusion Criteria

1.Children ( 6-10 years ) who are chronically undernourished (non-edematous ) based on the recent 2007 WHO growth standards for school-age children.

2.Primary endpoint; Underweight defined by a z-score < -2 SD for weight-for-age.

3.Secondary end point; stunting defined by a z-score of <-2 SD height-for-age will be used as for selection of children.

4.A z-score <-1SD weight-for-height to identify wasting, and MUAC, <12.5 cm, will be used as an additional marker for undernourishment.

5.Who are positive for any intestinal parasites.

6.Serum albumin concentrations (30-50 g/L), in childrens who tested positive for intestinal parasites.

Exclusion Criteria

The following will be exclusion criteria for the study;

1. Children who do not follow the above selection criterion will be excluded.

2. Who are malnourished with edema will be excluded from the study.

3. Severally malnourished/ or Healthy children.

4. Children who are suffering from any other (previously reported) illness like, heart, kidney, lungs etc.

5. Who feel uncomfortable to undergo the experimental procedure.

6. If parents do not allow their children to participate, will also be an exclusion criteria for the study.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
To determine the protein requirements in chronically malnourished children of school-age (6-10y) using the minimally invasive indicator amino acid oxidation (IAAO) method. <br/ ><br>Timepoint: Two times points (each before treatment for parasites and after treatment for testing 2 different levels of protein (low and high)based on habitual dietary intake. <br/ ><br>

Secondary Outcome Measures

Name	Time	Method
To assess the impact of antiparasite treatment in the same chronically undernourished children on protein requirements. <br/ ><br>Timepoint: Two times points (each before treatment for parasites and after treatment for testing 2 different levels of protein (low and high)based on habitual dietary intake. <br/ ><br>