Phenotypic characterization by impression cytology of the corneal surface reconstructed by simple limbal epithelial transplantatio
- Conditions
- imbal stem cell deficiency after SLETLimbal stem cell deficiencyLSCDSimple limbal epithelium transplantationSLETLimbal stem cellsStem cellsCornea
- Registration Number
- TCTR20160310002
- Lead Sponsor
- Faculty of Medicine Siriraj Hospital, Mahidol University
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 10
1. Patients with unilateral or bilateral limbal stem cell deficiency (LSCD) from various causes including Stevens-Johnson syndrome, chemical or thermal burns, chronic keratitis, multiple corneal surgeries, and prolonged use of eye drops
2. Patients having experienced auto-SLET or allo-SLET
3. Patients who used to have been diagnosed total LSCD in the SLET-treated eye
4. Patients who have been diagnosed LSCD with impression cytology before receiving SLET
1.Patients aged below 18 years
2. Patients who used to have been diagnosed partial LSCD in the SLET-treated eye
3. Patients having received penetrating keratoplasty following SLET
4. HIV-infected patients
5. Patients with ongoing eye infection
6. Patients with uncontrolled glaucoma
7. Patients with pregnancy
8. Patients unable to follow-up
9. Patients with non-compliance, physically or mentally
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Characteristics of impression cytology of cornea after SLET Three time points of 3-month interval, all post-operative Impression cytology and immunofluorescence for specific markers of corneal and conjunctival epitheli
- Secondary Outcome Measures
Name Time Method Correlation of impression cytology with in vivo confocal microscopy and clinical outcome Three time points of 3-month intervall, all post-operative Impression cytology, slit-lamp examination and in vivo confocal microscopy