Efficacy of Sodium Oxybate to promote sleep in the ICU: A randomized controlled trial - Sodium oxybate to promote sleep in the IC

eids Universitair Medisch Centrum0 个研究点目标入组 38 人开始时间: 待定最近更新: 2024年4月23日

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•Admission to the ICU/MCU;
•Expected duration of ICU/MCU admission > 2 nights after detection of sleep
•difficulties ;
•Awake, conscious (patients can be intubated);
•RASS (Richmond Agitation-Sedation Scale) score >= -2;
•The patient is experiencing sleep difficulties based on their own or clinical
•judgment as well as on a low score (<60% average score) on the Richard Campbell
•Sleep Questionnaire;
•The ICU physician intends to prescribe general sleep promoting measures as well
•as a benzodiazepine because of the sleep problems.

•Use of sedatives (dexmedetomidine, temazepam, oxazepam, propofol, midazolam)
•for sleep problems except for a low dose of sufentanil (up to 5 µg/hr) in
•intubated patients since this dose is frequently needed to counteract laryngeal
•tube irritation;
•Use of certain medication before inclusion:
•- More than 1 night of temazepam use: 1 night washout before inclusion;
•- Propofol: 1 night washout before inclusion;
•- Midazolam: 2 nights washout before inclusion.
•Current use of haloperidol, except a maintenance dose in patients recovering
•from a delirium;
•RASS score < -2;
•Active delirium, as assessed by the ICDSC-NL score;
•SSADH-deficiency;
•Severe depression;
•Planned ICU admission time < 3 nights after detection of sleep difficulties.

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