Tracking a Tactile Signal Along the Nervous System

Not Applicable

Recruiting

• Conditions: Stroke; Tactile Perception
• Interventions: Behavioral: Tactile stimulation

• Registration Number: NCT06231810
• Lead Sponsor: Virginia Polytechnic Institute and State University

Brief Summary

Quantify the flow of a tactile signal from the stimulus at the finger at the peripheral nervous system (PNS), to the central nervous system (CNS), and to cognitive perception at the brain in young adults (Aim 1) and individuals with and without stroke (Aim 2).

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2024-01-08
• Study First Submitted QC: 2024-01-26
• Study First Posted: 2024-01-30
• Study Start: 2024-02-29
• Status Verified: 2024-03
• Last Update Submitted: 2024-03-22
• Last Update Posted: 2024-03-26
• Primary Completion: 2027-07-01
• Study Completion: 2028-07-01

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

-right-hand dominance for participants who are neurotypical

For Aim 1:

-age range of 18-23

For Aim 2:

• participants who are neurotypical will be a similar age to the participants with stroke
• participants who are neurotypical will have no musculoskeletal and neurological conditions
• participants with stroke will have a single stroke incident resulting in a unilateral lesion (ischemic and hemorrhagic)
• participants with stroke will be in the chronic phase (>1 year from stroke onset)
• participants with stroke will have an onset of stroke after the age of 18
• participants with stroke who meet the criteria of having the capacity to provide informed consent, regardless of aphasia

Read More

Exclusion Criteria

• minors
• pregnant women
• prisoners
• adults not capable of consenting on their own behalf.

For Aim 2:

• participants with stroke who have used antispastic injections in the past six months
• participants with stroke who have a lesion in the brainstem and/or cerebellum
• participants with stroke who have a stroke arising due to brain surgery
• participants with stroke who have hemineglect

Read More

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
Stimulus magnitude	Tactile stimulation	Differing levels of tactile stimulus will be applied

Primary Outcome Measures

Name	Time	Method
Conscious detection threshold	30 minutes during the first session of a one session protocol	The magnitude at which a force stimulus applied to the finger can be first consciously detected. Different force levels will be applied, and the participant will indicate which of these forces can be detected. The changes in force applied will be in the units of N.

Secondary Outcome Measures

Name	Time	Method
Brain activation	60 minutes during the first session of a one session protocol	The magnitude and regions of brain activated in response to differing levels of force stimuli will be captured using fMRI. The % signal change in the brain will be used to define the brain activation in response to each force stimulus level.

Trial Locations

Locations (1)

Virginia Tech; 🇺🇸 Roanoke, Virginia, United States