Efficacy of memantine treatment for the prevention and restoration to cognitive dysfunction in high grade glioma patients receiving radiotherapy combined with hyperbaric oxygenation: randomized phase 3 study

Ishiuchi Shogo0 个研究点目标入组 29 人开始时间: 2019年6月5日最近更新: 2023年10月17日

适应症

试验速览

暂无简介。

•Patients with malignant glioma who are classified as Grade3 to 4 of WHO classification 2016 using neuroradiological and histopathological diagnostic methods and undergo hyperbaric oxygen therapy and irradiation therapy.

•1. Patients with hypersensitivity to the study drug.
•2. Patients with impaired renal function.
•3. Patients with factors that raise urine pH (tubular acidosis, severe urinary tract infection etc.).
•4. Patients with advanced liver function disorder.(1. Increase in T-Bil, AST, ALT, ALP, gamma-GTP of CTACAE v4.0 grade2 or more, 2. Accompanied by abnormality of coagulation factor, 3. Suspected diseases of hepatobiliary system etc.).
•5. Pregnant women, lactating women or ladies who may be pregnant.
•6. Patients who require continued administration of drugs that may interact with the study drug (Dopamine agonist, hydrochlorothiazide, drug excreted by renal tubule secretion, drug causing urinary alkalization, drug having NMDA receptor antagonism).
•7. Patients judged inappropriate as subjects of this study by research doctors.

发起方

Ishiuchi Shogo