Cutaneous Diphtheria in France : an Observational, Retrospective Study of Epidemiological, Clinical, Microbiological and Therapeutic Characteristics
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 63
- 试验地点
- 42
- 主要终点
- Patients epidemiological data description
研究概览
简要总结
Toxigenic cutaneous diphtheria is a notifiable disease that is re-emerging in the world and particularly in France. A better description of the epidemiological characteristics, as well as a refinement of the clinical characteristics of patients with cutaneous diphtheria, are essential to better understand this pathology, which has important public health issues and whose diagnosis absence can have catastrophic consequences for the patient and their contacts. Microbiological data (species identification, toxigenicity or not, resistance profile...) will be transmitted by the national reference center for corynebacteria of the diphtheriae complex and then caregivers who have managed the corresponding patients with cutaneous diphtheria will be contacted.
研究设计
- 研究类型
- Observational
- 观察模型
- Other
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Culture or PCR positive skin samples for corynebacteria diphtheria, ulcerans, pseudotuberculosis, belfantii or rouxii
- •Patient living in metropolitan France
排除标准
- •Patient opposition
结局指标
主要结局
Patients epidemiological data description
时间窗: 3 months
Epidemiological data will be collected to describe the studied population (age, sex, place of birth, vaccination status...)
Patients therapeutic data description
时间窗: 3 months
Therapeutic data will be collected to describe the studied population (antibiotic therapy, duration of treatment, search for an eradication a posteriori...)
Patients clinical data description
时间窗: 3 months
Clinical data will be collected to describe the studied population (history, description of lesions, disease evolution, complications...)
Patients microbiological data description
时间窗: 3 months
Microbiological data will be collected to describe the studied population (species identification, toxigenicity, presence of a co-infection...)
次要结局
- Comparison of post-infection serological sampling to national recommendations issued by the High Committee of Public Health(3 months)
- Comparison of patient isolation procedures to national recommendations issued by the High Committee of Public Health(3 months)
- Comparison of immunization status monitoring to national recommendations issued by the High Committee of Public Health(3 months)
- Comparison of antibiotic therapy duration to national recommendations issued by the High Committee of Public Health(3 months)
- Comparison of patient post infection vaccination status to national recommendations issued by the High Committee of Public Health(3 months)
- Comparison of patient microbiological follow-up to national recommendations issued by the High Committee of Public Health(3 months)