Cutaneous Diphtheria in France : Observational, Retrospective Study of Patient Characteristics
- Conditions
- Corynebacterium Diphtheriae Infection
- Interventions
- Other: Characteristics description
- Registration Number
- NCT05798247
- Lead Sponsor
- Centre Hospitalier Intercommunal de Toulon La Seyne sur Mer
- Brief Summary
Toxigenic cutaneous diphtheria is a notifiable disease that is re-emerging in the world and particularly in France. A better description of the epidemiological characteristics, as well as a refinement of the clinical characteristics of patients with cutaneous diphtheria, are essential to better understand this pathology, which has important public health issues and whose diagnosis absence can have catastrophic consequences for the patient and their contacts. Microbiological data (species identification, toxigenicity or not, resistance profile...) will be transmitted by the national reference center for corynebacteria of the diphtheriae complex and then caregivers who have managed the corresponding patients with cutaneous diphtheria will be contacted.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 63
- Culture or PCR positive skin samples for corynebacteria diphtheria, ulcerans, pseudotuberculosis, belfantii or rouxii
- Patient living in metropolitan France
- Patient opposition
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Arm && Interventions
Group Intervention Description Patients with cutaneous diphteria Characteristics description The study group consists of all the patients suffering from cutaneous diphtheria in metropolitan France and for which microbiological data were registered by the National Reference Center fo corynebacteria of the diphteriae complex between 2018 and 2022.
- Primary Outcome Measures
Name Time Method Patients epidemiological data description 3 months Epidemiological data will be collected to describe the studied population (age, sex, place of birth, vaccination status...)
Patients therapeutic data description 3 months Therapeutic data will be collected to describe the studied population (antibiotic therapy, duration of treatment, search for an eradication a posteriori...)
Patients clinical data description 3 months Clinical data will be collected to describe the studied population (history, description of lesions, disease evolution, complications...)
Patients microbiological data description 3 months Microbiological data will be collected to describe the studied population (species identification, toxigenicity, presence of a co-infection...)
- Secondary Outcome Measures
Name Time Method Comparison of post-infection serological sampling to national recommendations issued by the High Committee of Public Health 3 months Whether a post-infection serological sampling was performed or not will be collected.
Comparison of patient isolation procedures to national recommendations issued by the High Committee of Public Health 3 months Patient isolation or not will be collected.
Comparison of immunization status monitoring to national recommendations issued by the High Committee of Public Health 3 months Monitoring of immunization status or not will be collected
Comparison of antibiotic therapy duration to national recommendations issued by the High Committee of Public Health 3 months Duration of antibiotic therapy implemented by clinicians will be compared to national recommendations
Comparison of patient post infection vaccination status to national recommendations issued by the High Committee of Public Health 3 months Post-infection vaccination or not will be collected
Comparison of patient microbiological follow-up to national recommendations issued by the High Committee of Public Health 3 months Microbiological follow-up with eradication research or not will be collected.
Trial Locations
- Locations (42)
Centre Hospitalier de Brive
🇫🇷Brive-la-Gaillarde, Corrèze, France
Hôpital Avicenne Bobigny (AP-HP)
🇫🇷Bobigny, Seine-Saint-Denis, France
Hôpital Nord Franche-Comté
🇫🇷Trévenans, Territoire De Belfort, France
CHU de Montpellier
🇫🇷Montpellier, Hérault, France
CHRU de Tours
🇫🇷Chambray-lès-Tours, Indre-et-Loire, France
Centre Hospitalier de Briançon
🇫🇷Briançon, Hautes-Alpes, France
CHU de Caen
🇫🇷Caen, Calvados, France
Centre Hospitalier Régional d'Orléans
🇫🇷Orléans, Loiret, France
Centre Hospitalier de Saint-Lo
🇫🇷Saint-Lô, Manche, France
Groupement Hospitalier Nord Dauphiné
🇫🇷Bourgoin-Jallieu, Isère, France
Hôpital Ambroise Paré (AP-HP)
🇫🇷Boulogne-Billancourt, Hauts-de-Seine, France
Centre Hospitalier de Lourdes
🇫🇷Lourdes, Hautes-Pyrénées, France
CHU de Saint-Etienne
🇫🇷Saint-Priest-en-Jarez, Loire, France
Hôpital Henri Mondor (AP-HP)
🇫🇷Créteil, Val-de-Marne, France
HIA Sainte Anne
🇫🇷Toulon, VAR, France
CHU Bordeaux
🇫🇷Bordeaux, Gironde, France
Centre Hospitalier Sud Francilien
🇫🇷Corbeil-Essonnes, Essonne, France
Hôpital Américain de Paris
🇫🇷Neuilly-sur-Seine, Hauts-de-Seine, France
Centre Hospitalier d'Avignon
🇫🇷Avignon, Vaucluse, France
CHU de Nantes
🇫🇷Nantes, Loire-Atlantique, France
Centre Hospitalier William Morey
🇫🇷Chalon-sur-Saône, Saône-et-Loire, France
CHU de Lille
🇫🇷Lille, Nord, France
Centre Hospitalier de Valenciennes
🇫🇷Valenciennes, Nord, France
Centre Hospitalier de Mâcon
🇫🇷Mâcon, Saône-et-Loire, France
CHU d'Amiens
🇫🇷Amiens, Somme, France
Institut Hospitalo-Universitaire de Marseille
🇫🇷Marseille, Bouches-du-Rhône, France
CHU de Dijon
🇫🇷Dijon, Bourgogne, France
Centre Hospitalier de Guingamp
🇫🇷Pabu, Côtes d'Armor, France
Centre Hospitalier Alpes-Leman CHAL
🇫🇷Contamine-sur-Arve, Haute-Savoie, France
Centre Hospitalier Cholet
🇫🇷Cholet, Maine-et-Loire, France
Centre Hospitalier de Cahors
🇫🇷Cahors, Lot, France
Centre d'endocrinologie
🇫🇷Cabestany, Pyrénées Orientales, France
Hôpital Edouard Herriot (HCL)
🇫🇷Lyon, Rhône, France
Hôpital Croix rousse (HCL)
🇫🇷Lyon, Rhône, France
Centre Hospitalier Départemental de Vendée
🇫🇷La Roche-sur-Yon, Vendée, France
Hôpital Saint Joseph
🇫🇷Paris, France
Groupement Hospitalier Diaconesses Croix Saint Simon
🇫🇷Paris, France
Hôpital Saint Louis
🇫🇷Paris, France
Hôpital Saint Antoine
🇫🇷Paris, France
Hôpital La Pitié Salpêtrière
🇫🇷Paris, France
CHU de Toulouse - Hôpital La Grave
🇫🇷Toulouse, France
Hôpital Louis Pasteur (HCC)
🇫🇷Colmar, Haut-Rhin, France