Prospective Study for Symptomatic Relief of Essential Tremor With Cala Therapy
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 263
- 试验地点
- 63
- 主要终点
- TRG (Tremor Research Group) Essential Tremor Rating Assessment Scale (TETRAS) Subset Score
研究概览
简要总结
Prospective, multi-center, single-arm, non-significant risk study designed to evaluate the Cala TWO device. Subjects will be screened for eligibility and fitted with a Cala TWO device. Subjects will wear the device at home for a period of 3 months, during which they will be asked to stimulate their dominant hand twice a day. The stimulation amplitude will be based on each subject's stimulation threshold. Subjects will have in clinic assessments at enrollment, month 1 and 3.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 22 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Must be ≥22 years of age
- •Competent and willing to provide written, informed consent to participate in the study
- •A diagnosis of essential tremor as confirmed from clinical history and examination by a movement disorder neurologist
- •A tremor severity score of 2 or above in the dominant hand/arm as measured by any one of the TETRAS upper limb items and a minimum subset score of 6 across all upper limb items
- •Significant disability due to essential tremor (Bain & Findley score of 3 or above in any one of the upper limb items and a minimum subset score of 8 across all upper limb items)
- •Stable dose of tremor medications, if applicable, for 30 days prior to study entry
- •Stable dose of antidepressant medications, if applicable, for 90 days prior to study entry
- •Willing to comply with study protocol requirements including:
- •remaining on a stable dosage of tremor and antidepressant medications, if applicable, during the duration of the study
- •no significant alcohol or caffeine consumption within 8 hours prior to study visits
- •no usage of the Cala TWO device within 8 hours prior to study visits
排除标准
- •Moderate to severe ethanol dependence as defined by the criteria outlined in the DSM-5 (score of 4 or higher)
- •Implanted electrical medical device, such as a pacemaker, defibrillator, or deep brain stimulator, or implanted metal in the wrist to be stimulated
- •Previous thalamotomy procedure, including stereotactic thalamotomy, gamma knife radiosurgical thalamotomy, and focused ultrasound for the treatment of tremor
- •Suspected or diagnosed epilepsy or other seizure disorder
- •Swollen, infected, inflamed areas, or skin eruptions, open wounds, or cancerous lesions of skin at stimulation site
- •Peripheral neuropathy affecting the tested upper extremity
- •Presence of any other neurodegenerative disease like Parkinson-plus syndromes suspected on neurological examination. These include: multisystem atrophy, progressive supranuclear palsy, dementia with Lewy bodies, and Alzheimer's disease.
- •Anyone suspected to have the diagnosis of idiopathic Parkinson's disease (PD). This includes excluding anyone with the presence of parkinsonian features including bradykinesia rigidity, or postural instability. Subjects who exhibit only mild resting tremor but no other symptoms or signs of PD may be included.
- •Botulinum toxin injection for hand tremor within 6 months prior to study enrollment
- •Are participating or have participated in another interventional clinical trial in the last 30 days which may confound the results of this study, unless approved by the Sponsor
- •Significant alcohol or caffeine consumption within 8 hours prior to study enrollment, which may confound the results of the study, where significant caffeine is considered more than 95 mg (equivalent to a cup of coffee), and significant alcohol is considered more than 14 g (equivalent to 5 oz of wine, 12 oz of beer, or 1.5 oz of distilled spirits).
- •Subjects unable to communicate with the investigator and staff
- •Any health condition that in the investigator's opinion should preclude participation in this study
- •Pregnancy or anticipated pregnancy during the course of the study
结局指标
主要结局
TRG (Tremor Research Group) Essential Tremor Rating Assessment Scale (TETRAS) Subset Score
时间窗: Baseline to 3-months
Tremor Research Group (TRG) Essential Tremor Rating Assessment Scale (TETRAS) subset score: TETRAS subset score relevant to the stimulated upper limb. The subset score is the sum of 6 rated tasks. Each task is rated 0 to 4, where a higher score indicates more severe tremor. Minimum subset score = 0; Maximum subset score = 24.
Bain & Findley Activities of Daily Living (ADL) Scale Subset Score
时间窗: Baseline to 3-months
Bain \& Findley ADL subset score relevant to the stimulated upper limb. The subset score is the sum of 8 rated tasks. Each task is rated 1 to 4, where a higher score indicates more severe tremor. Minimum subset score = 8; Maximum subset score = 32.
次要结局
- Kinematic Measurements, as Collected With the Device During Postural Holds, Change From Pre-stimulation to Post-stimulation Across Sessions(Average change in tremor power over 3-month study period)