Influence of individual hemolysis, haptoglobin- genotype and CD 163 Receptor-activity on acute kidney injury in cardiac surgery patients.

• Conditions: N17.9; Z95.1; Acute renal failure, unspecified; Presence of aortocoronary bypass graft

• Registration Number: DRKS00005457
• Lead Sponsor: niversitätsmedizin Göttingen

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2013-11-26
• Study Completion: 2014-04-01
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Complete
• Sex: All
• Target Recruitment: 150

Inclusion Criteria

Aorto-coronare Bypass surgery

Exclusion Criteria

Extracorporale membranoxygenation,
kidney failure requiering dialysis
aortokoronare Bypass-surgery in combination with
impossible consent Information,
incomplete datasets

Study & Design

• Study Type: observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Bloodprobes for determination of Haptoglobin and free hemoglobin concentration preoperative (after anesthesia induction), intraoperative (Start and End) and postoperative (surgery-day and day 1)<br>Analysis of haptoglobin Genotyp and CD 163 receptor acitivity.

Secondary Outcome Measures

Name	Time	Method
Acute kidney injury<br>day one to five according to AKIN Criteria (diureses and Serum creatinine) and evaluation of the concentration of the biomarkers TIMP-2 and IGFBP-7.