Osteoporosis and Dental Implant
- Registration Number
- NCT00727493
- Lead Sponsor
- Charite University, Berlin, Germany
- Brief Summary
The purpose of this study is to evaluate the influence of alendronate therapy on the wound healing after dental implants in patients with osteoporosis.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- Female
- Target Recruitment
- 45
Inclusion Criteria
- Postmenopausal women > 2 years after menopause
- Age between 60 and 75 years
- Possibility to insert a dental implant
- Osteoporosis as defined by WHO criteria (intervention group), or women without osteoporosis / osteopenia (non-intervention group)
Exclusion Criteria
- Pathological findings in the jaw bone
- Chronic inflammatory rheumatoid disease
- Bisphosphonate treatments during the last 12 months
- Inflammatory or metabolic bone disease, excluding osteoporosis
- Systemic corticosteroid treatments of more than one month within previous 12 months
- Severe diseases with life expectancy less than one year or expectation of rapid worsening within one year
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description 1 alendronate once weekly 70mg alendronate once weekly 70mg, calcium 1000mg and Vitamin D 800 IU daily, dental implant 2 placebo placebo once weekly, calcium 1000mg and Vitamin D 800 IU daily; dental implant
- Primary Outcome Measures
Name Time Method Dental CT baseline, and 3,6,12 months after baseline
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Centre for Muscle and Bone Research, Charité - Campus Benjamin Franklin
🇩🇪Berlin, Germany