The effect of silymarin on serum liver enzyme level in patients with trauma

Phase 3

Recruiting

• Conditions: iver Trauma.; Contusion of liver; S36.112

• Registration Number: IRCT20190911044744N1
• Lead Sponsor: Shiraz University of Medical Sciences

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 5 November 2019

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 90

Inclusion Criteria

People aged 16 or over
Not taking a known hepatotoxic drug
Not taking oral silymarin during the past day
No confirmed history of allergic reactions following oral administration of silymarin
Alanine aminotransferase (ALT) levels more than 2-fold above normal (> 70 IU / L) up to 4-fold above normal Or aspartate aminotransferase (AST) levels more than 2-fold above normal (> 70 IU / L) up to 4-fold above normal
Not taking concomitant antioxidants or compounds such as vitamin A, C, E and N-acetyl cysteine
Oral tolerance to medications

Exclusion Criteria

Pregnancy or lactation
History of advanced liver disease

Study & Design

• Study Type: interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Decreased liver enzyme levels. Timepoint: Start of study, end of first week, end of second week. Method of measurement: Blood test.;Measurement of free radicals. Timepoint: The beginning and the end of the study. Method of measurement: Blood test.