Clinical significance of diffusion MRI in patients with moyamoya disease
Not Applicable
- Conditions
- moyamoya disease (children and adults)
- Registration Number
- JPRN-UMIN000023082
- Lead Sponsor
- Tokyo Medical and Dental University, Department of Neurosurgery
- Brief Summary
This study revealed that patients with moyamoya disease suffer from chronic ischemic damage to the brain microstructure, i.e. decreased neurite density and simplified network complexity, and the degree of ischemic damage is related to neurocognitive dysfunction and the degree of hemodynamic and metabolic dysfunction. We also found that diffusion magnetic resonance imaging might be used to noninvasevely evaluate cerebral hemodynamic impairment in patients with moyamoya disease.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete: follow-up complete
- Sex
- All
- Target Recruitment
- 31
Inclusion Criteria
Not provided
Exclusion Criteria
1. patients with quasi-moyamoya disease 2. contraindication of MRI examination 3. brain lesion other than moyamoya disease affecting MRI parameters (e.g. brain tumor, venous angioma) 4. judged as inappropriate participants by doctor-in-charge
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method 1. Comparing diffusion MRI parameters (ADC, FA, Vic, Viso and OD of NODDI) with scores of neurophysiological tests( WISC or WAIS, WCST, stroop test, word fluency test, TMT, and the BIg Five Personal Inventory or NEO-FFI)
- Secondary Outcome Measures
Name Time Method 2. Comparing diffusion MRI (ADC, FA, Vic, Viso and OD of NODDI) of patients with moyamoya disease and of age-sex matched normal healthy volunteers. 3. Comparing diffusion MRI(D* and f map of IVIM, and ADC, FA, Vic, Viso and OD of NODDI) and 15Ogas PET (CBF, CBV, OEF and CMRO2).