Comparison of effect of propofol and sevoflurane optic nerve sheath diameter in patients undergoing laproscopic procedures
试验速览
- 阶段
- 4 期
- 状态
- 尚未招募
- 发起方
- 入组人数
- 132
- 试验地点
- 1
- 主要终点
- Measurement of optic nerve sheath diameter using ultrasound
研究概览
简要总结
A total of 132 patients belonging to age group of18 to 65years , ASA class I and II scheduled for elective laproscopic procedures will be prospectively studied. In this double-blinded randomized control trial, a total of 132 participants will be allocated into two groups - GROUP A – Patients will be administered after standardised GA induction with Inj. Propofol titrated in TCI @ 2.5mg/kg for Propofol infusion for maintanence ) and GROUP B- Patients will be administered after standardised GA induction with Inh. Sevoflurane titrated such that end tidal Sevoflurane is maintained at 1.0-1.5 MAC ). ONSD will be measured at various time intervals before induction, after intubation, t15min, t 30mins,t 45mins,t 60mins,t90mins,t120mins,t150mins…,post extubation ,postopervatively . Data collection will be done by observation and measurement of various parameters.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 盲法
- Participant and Investigator Blinded
入排标准
- 年龄范围
- 18.00 Year(s) 至 65.00 Year(s)（—）
- 性别
- All
入选标准
- •Age 18-65 ASA PS 1-2 Both sexes.
- •Elective laproscopic surgeries for more than 1 hour.
排除标准
- •Ophthalmological diseases Pituitary adenoma Brain Tumour CVA Meningitis Patient refusal.
结局指标
主要结局
Measurement of optic nerve sheath diameter using ultrasound
时间窗: 0MIN,5MINS,15MIN , 45MIN,60MIN,90MIN,120MIN,
次要结局
- Hemodynamic parameters like heart rate , blood pressure.(Correlation with the maximum intra abdominal pressure during surgery)
研究者
Dr T Shalini
SRM Medical College and Research Institute