Therapeutic Efficacy of Categorical Language Fluency Smartphone Game Application

Not Applicable

Completed

• Conditions: Mild Cognitive Impairment; Alzheimer's Disease
• Interventions: Device: Categorical Language Fluency Smartphone Application

• Registration Number: NCT02848404
• Lead Sponsor: Seoul National University Bundang Hospital

Brief Summary

The purpose of this study is to examine therapeutic efficacy of categorical language fluency smartphone game application in mild cognitive impairment and mild Alzheimer's dementia.

Detailed Description

The Categorical Language Fluency Smartphone Game Application was developed based on the semantic distance training, which was effective in improving categorical language fluency of mild cognitive impairment and mild Alzheimer's dementia. 10 patients with mild cognitive impairment and another 10 patients with mild Alzheimer's dementia were recruited to examine therapeutic efficacy of the application.

Study Timeline

• Study Start: 2016-06
• Study First Submitted: 2016-07-20
• Study First Submitted QC: 2016-07-27
• Study First Posted: 2016-07-28
• Primary Completion: 2016-12
• Study Completion: 2017-02
• Status Verified: 2020-03
• Last Update Submitted: 2020-03-23
• Last Update Posted: 2020-03-25

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 20

Inclusion Criteria

• Aged above 55

• Confirmed literacy

  • Diagnosed to mild cognitive impairment by International Working Group on Mild Cognitive Impairment and Clinical Dementia Rating(CDR) of 0 or 0.5.
  • Diagnosed to possible or probable Alzheimer's dementia by NINCDS-ADRDA and Clinical Dementia Rating(CDR) of 1 or below.

Exclusion Criteria

• Evidence of delirium, confusion
• Any neurological conditions causing cognitive decline such as Parkinson's disease, brain hemorrhage, brain tumor, normal pressure hydrocephalus
• Evidence of severe cerebrovascular pathology
• History of loss-of-consciousness over 1 hour due to head trauma or repetitive head trauma of mild severity
• History of substance abuse or dependence such as alcohol
• Presence of depressive symptoms that could influence cognitive function
• Presence of medical comorbidities that could result in cognitive decline

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
Categorical Language Fluency Smartphone Application	Categorical Language Fluency Smartphone Application	Smartphone game application specifically aimed at training categorical language fluency

Primary Outcome Measures

Name	Time	Method
Application usage log	4-weeks treatment	Log to assess compliance of participant(by describing frequency and duration of training by using application)

Secondary Outcome Measures

Name	Time	Method
Subjective Memory Complaint Questionnaire	after 4-weeks treatment	to evaluate efficacy of application
Geriatric Depression Scale	after 4-weeks treatment	to evaluate efficacy of application
Korean version of MMSE for dementia screening	after 4-weeks treatment	to evaluate efficacy of application