Development and Evaluation of Buccal Mucoadhesive Polymer Formulations Containing Antifungal Drugs of the Management of Denture-Stomatitis
- Conditions
- Oral Health
- Registration Number
- PACTR202210598505787
- Lead Sponsor
- Department of Oral Medicine Periodontology Oral diagnosis and Radiology Faculty of Dentistry Alexandria University
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 48
Providing consent prior to participation in the study
Wearing a maxillary complete acrylic denture
Clinically diagnosed with grade II denture stomatitis
Cytologically diagnosed with denture stomatitis
Patients with systemic disease and conditions which predispose to Candida spp. (e.g.: diabetes, cardiovascular disease and viral hepatitis).
Smoking patients.
Having a history of chemotherapy/radiotherapy or under warfarin therapy
Patients with previous history of antifungal treatment.
Patients with history of corticosteroids (systemic or local buccal) within last 3 months.
Contact allergy.
Patient with history of antibiotics (systemic or local buccal) within one month from study.
Having oral mucosal lesions other than from denture stomatitis
Being scheduled to replace existing dentures with new ones during the period of the study
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Colony counting (Candida albicans Colony count)
- Secondary Outcome Measures
Name Time Method Visual Analogue Scale for Pain (VAS)