PACTR202210598505787
Completed
Phase 1
Development and Evaluation of Buccal Mucoadhesive Polymer Formulations Containing Antifungal Drugs of the Management of Denture-Stomatitis.
Department of Oral Medicine Periodontology Oral diagnosis and Radiology Faculty of Dentistry Alexandria University0 sites48 target enrollmentSeptember 24, 2022
Overview
- Phase
- Phase 1
- Intervention
- Not specified
- Conditions
- Not specified
- Sponsor
- Department of Oral Medicine Periodontology Oral diagnosis and Radiology Faculty of Dentistry Alexandria University
- Enrollment
- 48
- Status
- Completed
- Last Updated
- 2 years ago
Overview
Brief Summary
No summary available.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Providing consent prior to participation in the study
- •Wearing a maxillary complete acrylic denture
- •Clinically diagnosed with grade II denture stomatitis
- •Cytologically diagnosed with denture stomatitis
Exclusion Criteria
- •Patients with systemic disease and conditions which predispose to Candida spp. (e.g.: diabetes, cardiovascular disease and viral hepatitis).
- •Smoking patients.
- •Having a history of chemotherapy/radiotherapy or under warfarin therapy
- •Patients with previous history of antifungal treatment.
- •Patients with history of corticosteroids (systemic or local buccal) within last 3 months.
- •Contact allergy.
- •Patient with history of antibiotics (systemic or local buccal) within one month from study.
- •Having oral mucosal lesions other than from denture stomatitis
- •Being scheduled to replace existing dentures with new ones during the period of the study
Outcomes
Primary Outcomes
Not specified
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