Absolute Quantification in Bone Scintigraphy: Phantom Evaluation and Clinical Application in Patients Undergoing Follow-up for Vertebral Fractures.
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 21
- 试验地点
- 3
- 主要终点
- To validate the absolute bone scan quantification in a retrospectively selected patient population
研究概览
简要总结
While absolute quantification in 18F-FDG PET (Positon Emission Tomography) is widely used in clinical routine, absolute quantification in SPECT (Single Photon Emission Computed Tomography) is under development and its clinical interest remains to be demonstrated. Recent studies carried out on bone scan recordings show the potential interest of quantification indexes such as SUV (Standard Uptake Value).
详细描述
In oncology, bone scan studies have reported significantly higher SUV values for secondary bone lesions compared with benign osteoarticular lesions , and some have even defined an SUVmax threshold value that points to prostatic bone metastases.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients with recent vertebral fractures:
- •who have had at least two SPECT/CT scan scans of the spine as part of a pre-vertebroplasty check-up,
- •for which fracture dates were known.
排除标准
- •Minor person
- •Person opposing the use of their data (Posters in waiting rooms explaining that the patient must object if they do not wish their data to be used)
结局指标
主要结局
To validate the absolute bone scan quantification in a retrospectively selected patient population
时间窗: After 1 year
Analysis of SUV variation on at least 2 bone scans: Variation of the SUV over time on scans of patients with spinal fractures
次要结局
- To calibrate the tomographic images from the gamma camera(1 day)
- To evaluate the attenuation correction on phantoms of different density(1 day)
- To evaluate absolute quantification on phantoms(1 day)
研究者
Pierre Yves MARIE
Study director
Central Hospital, Nancy, France