跳至主要内容
临床试验/NCT04169204
NCT04169204进行中(未招募)不适用

Very Old Intensive Care Patients - Perfusion (VIPPER)

Heinrich-Heine University, Duesseldorf1 个研究点 分布在 1 个国家目标入组 47 人开始时间: 2020年5月19日最近更新:
适应症

试验速览

阶段
不适用
状态
进行中(未招募)
发起方
入组人数
47
试验地点
1
主要终点
bedside measurement of sublingual microcirculation

研究概览

简要总结

Shock is a frequent, etiologically heterogeneous and often lethal clinical condition of intensive care medicine. This is particularly true for very old intensive care patients (VIPs), who are among the fastest-growing subgroups of all intensive care unit (ICU) patients and who suffer from a significantly impaired outcome. In addition to the treatment of the causes of shock, current therapeutic approaches focus on the stabilization of vital parameters, which in general all reflect macrocirculatory measured values such as blood pressure. In contrast, a disturbance of the microcirculation (blood circulation of the smaller blood vessels <100 µm) is only poorly measurable and delayed. The last generation of AVA-Software (MicroVisionMedical) will calculate different parameters about the capillary densitiv and perfusion in a user-independent way. VIPPER investigates whether a non-invasive measurement of microcirculation using the sublingual mucosa in very old intensive care patients in shock leads to faster recognition and specific treatment of organ dysfunctions. Secondly, this study checks whether this measurement predicts outcome.

研究设计

研究类型
Observational
观察模型
Cohort
时间视角
Prospective

入排标准

年龄范围
80 Years 至 —(Older Adult)
性别
All
接受健康志愿者

入选标准

  • ≥ 80 years
  • Acute ICU admission
  • Shock at the time point of admission to the ICU or in the first 3 hours defined as Lactate ≥ 2 mmol/l AND need for vasoactive substances to maintain a MAP ≥ 65 mmHg in the presence of adequate volume status

排除标准

  • < 80 years
  • Inaccessibility for sublingual measurement
  • no informed consent

结局指标

主要结局

bedside measurement of sublingual microcirculation

时间窗: after 24 hours

measurement of sublingual microcirculation by using MicroScan® microscope

次要结局

  • Mortality(after 30 days, 6 months and 12 months)
  • Use of Vasopressors and fluids(days from admission of the intensive care unit until discharge)
  • Length of stay at ICU(tdays from admission of the intensive care unit until discharge)

研究者

发起方
Heinrich-Heine University, Duesseldorf
申办方类型
Other
责任方
Sponsor

研究点 (1)

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