Exploration of the effects of high frequency stimulation induced secondary hyperalgesia on the NDT-EP method.

Completed

Conditions: (chronic pain), peripheral sensitization, central sensitization
Chronic Pain

Registration Number: NL-OMON49836

Lead Sponsor: niversity of Twente

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Completed

Sex: Not specified

Target Recruitment: 20

Inclusion Criteria

Age between 16 and 40 years old.

Exclusion Criteria

* Participant refusal during the study.
* Language problems.
* Skin problems at site of stimulation or EEG recording.
* Diabetes.
* Implanted stimulation device.
* Pregnancy.
* Usage of analgesics within 24 hours before the experiment.
* Consumption of alcohol or drugs within 24 hours before the experiment.
* Pain complaints at the time of the experiment.
* A medical history of chronic pain.

Study & Design

Study Type: Observational non invasive

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>- NDTs Subject Response: The subjects response to the stimulus, detected or<br /><br>not detected.<br /><br>- EEG Signals: Electric signals reflecting the subjects neurophysiological<br /><br>activity related to the stimulus, extracted at a fixed interval around every<br /><br>stimulus.<br /><br>- NRS after HFS stimulation: Scoring the intensity of pinpricks by means of<br /><br>numerical rating score after inducing secondary hyperalgesia using<br /><br>high-frequency stimulation.<br /><br>- Punctate mechanical stimulation: Pinprick stimulation using Semmes-Weinstein<br /><br>monofilaments for assessing the occurrence of secondary hyperalgesia</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>- Response Time: Subjects response time.<br /><br>- Participant Characteristics: Age and sex, handedness.<br /><br>- Electrode-skin Impedance: To assess whether the setup of the HFS was able to<br /><br>reach the required voltages for intensity 20 times higher the subjects<br /><br>detection threshold.</p><br>