A pilot investigation of coagulation and platelet function in the era of modern antiplatelet therapy and targeted temperature management for the treatment of acute coronary events after out of hospital cardiac arrest

niversity Hospitals Bristol NHS Foundation Trust (UK)0 个研究点目标入组 60 人开始时间: 2016年8月9日最近更新: 2019年9月9日

试验速览

•OHCA group:
•Any individual admitted to the Emergency Department following OHCA with return of spontaneous circulation (ROSC), who meets the Utstein criteria will be enrolled immediately upon arrival. The Utstein group is an internationally defined cohort of individuals who have a witnessed cardiac arrest, likely due to a heart attack and have a specific heart rhythm (VF or pulseless VT) on arrival of the Emergency Medical Service.
•For the STEMI group:
•Any patient brought to the coronary catheter laboratory or ED deemed to be having a STEMI by the clinical team and offered primary PCI will be eligible for enrolment.

•1. Patients currently detained by Her Majesty’s Prison Service
•2. Patients detained under the Mental Capacity act
•3. Patients known or suspected to be pregnant
•4. Patients known to lack capacity, for example known to have dementia
•The following OHCA patients will not be enrolled:
•1. Patients who suffer an in-hospital cardiac arrest
•2. Patients who arrive in ED in cardiac arrest and fail to achieve or maintain ROSC within 10 minutes
•3. Patients who have an unwitnessed arrest, OR an initial rhythm that is not ventricular fibrillation or ventricular tachycardia OR have an obvious non-cardiological cause (and so fail to meet Utstein criteria)
•4. Patients who have sustained ROSC but who it is felt will not benefit from admission to intensive care. The decision as to ICU suitability will be undertaken by the clinical team
•With regard to the STEMI group:
•1. Patients not meeting the ESC criteria for STEMI
•2. Patients lacking capacity (as deemed by the clinical team)
•3. Patients undergoing rescue PCI
•4. Patients not offered primary PCI
•5. Patients who have a period of cardiac arrest but regain consciousness

发起方

niversity Hospitals Bristol NHS Foundation Trust (UK)